ArticleProceedings of the National Academy of Sciences of the United States of America2020
Open access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Pooled it
- Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis.Rheumatology (Oxford, England) · 2021Pooled it
- Novel HLA class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease.Annals of the rheumatic diseases · 2026Article
- Recent Advances in Biomarkers of Systemic Sclerosis-Associated Interstitial Lung Disease: Clinical Relevance and Therapeutic Perspectives.Life (Basel, Switzerland) · 2026Review
- Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.Annals of the rheumatic diseases · 2026Article
- Centromeric α-satellite DNA is a hotspot of genotoxic damage, incomplete repair, and cytoplasmic mislocalization.bioRxiv : the preprint server for biology · 2026Article
- Association ofInternational journal of molecular sciences · 2026Article
- Centromere Instability Drives Chromosome Damage and Autoantigen Exposure in Systemic Sclerosis.bioRxiv : the preprint server for biology · 2025Article
- Systemic sclerosis: pathogenic mechanisms and their implications for treatment.Seminars in immunopathology · 2025Review
- Case report: anti-fibrillarin autoantibodies induced by viral molecular mimicry in a paediatric patient.Italian journal of pediatrics · 2025Article
- Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases.Journal of translational autoimmunity · 2025Review
- Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures.Clinics in orthopedic surgery · 2025Article
- Pathogenesis of systemic sclerosis: an integrative review of recent advances.Journal of rheumatic diseases · 2025Review
- HLA DRB1* Allele Lupus Erythematosus, Rheumatoid Arthritis, and other Autoimmune Disorders with Skin Involvement.Mediterranean journal of rheumatology · 2025Review
- An international perspective on the future of systemic sclerosis research.Nature reviews. Rheumatology · 2025Review
- Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review.Clinical rheumatology · 2024Review
- Cross-Phenotype GWAS Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.medRxiv : the preprint server for health sciences · 2024Article
- HLA Association among Thai Patients with Diffuse and Limited Cutaneous Systemic Sclerosis.Biomedicines · 2024Article
- A Prospective Observational Study of Disease Severity and Mortality in Hispanic American Patients With Systemic Sclerosis.Arthritis care & research · 2024Observational
- Phenotypes of patients with systemic sclerosis in the Chinese Han population: a cluster analysis.Clinical rheumatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 20 institutions in 1 country.
Pravitt GourhNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; dan.kastner@nih.gov pravitt.gourh@nih.gov.ORCID 0000-0002-6488-1850
Sarah A SafranNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Theresa AlexanderNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Steven E BoydenInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Nadia D MorganDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Ami A ShahDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Maureen D MayesDivision of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX 77030.
Ayo DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Daniel ShrinerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Robyn T DomsicDivision of Rheumatology & Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Thomas A MedsgerDivision of Rheumatology & Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Paula S RamosDivision of Rheumatology, Medical University of South Carolina, Charleston, SC 29425.ORCID 0000-0002-9433-6634
Richard M SilverDivision of Rheumatology, Medical University of South Carolina, Charleston, SC 29425.
Virginia D SteenDivision of Rheumatology, Georgetown University School of Medicine, Washington, DC 20007.
John VargaDivision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Vivien HsuDivision of Rheumatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903.
Lesley Ann SaketkooScleroderma Patient Care and Research Center, Tulane University, New Orleans, LA 70112.
Elena SchiopuDivision of Rheumatology, University of Michigan, Ann Arbor, MI 48109.
Dinesh KhannaDivision of Rheumatology, University of Michigan, Ann Arbor, MI 48109.
Jessica K GordonDepartment of Rheumatology, Hospital for Special Surgery, New York, NY 10021.
Brynn KronRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, CA 94115.
Lindsey A CriswellRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, CA 94115.
Heather GladueDepartment of Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC 28207.
Chris T DerkDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104.
Elana J BernsteinDivision of Rheumatology, New York Presbyterian Hospital, Columbia University, New York, NY 10032.
S Louis BridgesDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35233.
Victoria K ShanmugamDivision of Rheumatology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052.
Kathleen D KolstadDivision of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305.
Lorinda ChungDivision of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305.
Suzanne KafajaDivision of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Reem JanDivision of Rheumatology, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637.
Marcin TrojanowskiDivision of Rheumatology, Boston University Medical Center, Boston, MA 02118.
Avram GoldbergDivision of Rheumatology, NYU Langone Medical Center, New York, NY 10003.
Benjamin D KormanDivision of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642.
Peter J SteinbachCenter for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892.
Settara C ChandrasekharappaGenomics Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
James C MullikinNIH Intramural Sequencing Center, National Human Genome Research Institute, Rockville, MD 20852.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Charles RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Fredrick M WigleyDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Daniel L KastnerInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; dan.kastner@nih.gov pravitt.gourh@nih.gov.
Francesco BoinRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, CA 94115.
Elaine F RemmersInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
National Institutes of Health · USJohns Hopkins University · USUniversity of California, San Francisco · USMedical University of South Carolina · USUniversity of Michigan · USUniversity of Pittsburgh · USBoston University · USGeorgetown University · USGeorge Washington University · USHospital for Special Surgery · USNational Human Genome Research Institute · USNewYork–Presbyterian Hospital · USNorthwestern University · USNYU Langone Health · USRutgers, The State University of New Jersey · USStanford University · USTulane University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Chicago · US
Funding
Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6MGenetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MConvalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3MGenetic Analysis of Complex Inflammatory DisordersZIAHG200371 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2024
$18.8MNHGRI/DIR Genomics CoreZICHG200346 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI CHANDRASEKHARAPPA, SETTARA · 2010 to 2025
$14.5MSample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, Antony Rosen · 2016 to 2026
$8.9MRESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2MSimulating Protein Structures, Complexes, And DynamicsZIACT000265 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI STEINBACH, PETER J · 2009 to 2020
$8.2MMultidisciplinary Rheumatology Training ProgramT32AR048522 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, LIVIA A CASCIOLA-ROSEN · 2003 to 2026
$6.4MGenetics and Pathogenesis of SclerodermaZIAAR041209 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GOURH, PRAVITT · 2019 to 2024
$6.3MPatient Resource CoreP60AR062755 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GILKESON, GARY S · 2012 to 2016
$5.8MScreening Chest CT to Detect Interstitial Lung Disease in Systemic SclerosisK23AR075112 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERNSTEIN, ELANA · 2019 to 2023
$794kNCATS NIH HHS UL1 TR003167NIAMS NIH HHS K01 AR067280NIAMS NIH HHS K08 AR070285NIAMS NIH HHS K23 AR075112NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P30 AR070254NIAMS NIH HHS P60 AR062755NIAMS NIH HHS T32 AR048522
Abstract
Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined
Indexed as
AllelesAmino Acid SequenceAntigens, ViralAutoantibodiesAutoantigensBlack or African AmericanComputational BiologyDatasets as TopicFemaleGenetic Predisposition to DiseaseHLA AntigensHumansMaleMimiviridaeMolecular MimicryPhycodnaviridaeAntigens, ViralAutoantibodiesAutoantigensHLA AntigensautoantibodiesHLAmimivirusmolecular mimicryscleroderma
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.