ArticleProceedings of the National Academy of Sciences of the United States of America2020
Distinct effects of reward and navigation history on hippocampal forward and reverse replays.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- A likelihood-based method for identifying replay from spike sequences.Nature communications · 2026Article
- Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals.Nature communications · 2025Article
- Selective reactivation of value- and place-dependent information during sharp-wave ripples in the intermediate and dorsal hippocampus.Science advances · 2024Article
- Memory consolidation from a reinforcement learning perspective.Frontiers in computational neuroscience · 2024Article
- Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions.Current biology : CB · 2023Article
- Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion.bioRxiv : the preprint server for biology · 2023Article
- Dual credit assignment processes underlie dopamine signals in a complex spatial environment.Neuron · 2023Article
- Dual credit assignment processes underlie dopamine signals in a complex spatial environment.bioRxiv : the preprint server for biology · 2023Article
- Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions.bioRxiv : the preprint server for biology · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Synthetic Data Resource and Benchmarks for Time Cell Analysis and Detection Algorithms.eNeuro · 2023Article
- Article
- Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal.Nature communications · 2022Article
- Multiple-Timescale Representations of Space: Linking Memory to Navigation.Annual review of neuroscience · 2022Review
- Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice.Neuron · 2021Article
- Article
- Navigating for reward.Nature reviews. Neuroscience · 2021Review
- Distinct effects of reward and navigation history on hippocampal forward and reverse replays.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
To better understand the functional roles of hippocampal forward and reverse replays, we trained rats in a spatial sequence memory task and examined how these replays are modulated by reward and navigation history. We found that reward enhances both forward and reverse replays during the awake state, but in different ways. Reward enhances the rate of reverse replays, but it increases the fidelity of forward replays for recently traveled as well as other alternative trajectories heading toward a rewarding location. This suggests roles for forward and reverse replays in reinforcing representations for all potential rewarding trajectories. We also found more faithful reactivation of upcoming than already rewarded trajectories in forward replays. This suggests a role for forward replays in preferentially reinforcing representations for high-value trajectories. We propose that hippocampal forward and reverse replays might contribute to constructing a map of potential navigation trajectories and their associated values (a "value map") via distinct mechanisms.
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