ArticleProceedings of the National Academy of Sciences of the United States of America2019
Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.
- An MRI-Based, Data-Driven Model of Cortical Laminar Connectivity.Neuroinformatics · 2021Pooled it
- Trial
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- Blindness reveals that Heschl's gyrus folding is not altered by auditory experience.bioRxiv : the preprint server for biology · 2026Article
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI.Communications biology · 2026Article
- Distinct cortical excitability and connectivity profiles within the human SMA complex.bioRxiv : the preprint server for biology · 2026Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Intracerebral Transplantation of Enteric Glia.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Comparison of human and marmoset basic-level face categorization based on shape.Scientific reports · 2025Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Thalamus-cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.Cell reports · 2025Article
- Key Challenges and Optimization Practices for Non-clinical Evaluation of AAV based Gene Therapy for Central Nervous System Disease.Pharmaceutical research · 2025Review
- Understanding Tau pathology: Insights from animal models.Zoological research · 2025Review
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 4 countries.
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Abstract
Advances in neuroimaging and neuroanatomy have yielded major insights concerning fundamental principles of cortical organization and evolution, thus speaking to how well different species serve as models for human brain function in health and disease. Here, we focus on cortical folding, parcellation, and connectivity in mice, marmosets, macaques, and humans. Cortical folding patterns vary dramatically across species, and individual variability in cortical folding increases with cortical surface area. Such issues are best analyzed using surface-based approaches that respect the topology of the cortical sheet. Many aspects of cortical organization can be revealed using 1 type of information (modality) at a time, such as maps of cortical myelin content. However, accurate delineation of the entire mosaic of cortical areas requires a multimodal approach using information about function, architecture, connectivity, and topographic organization. Comparisons across the 4 aforementioned species reveal dramatic differences in the total number and arrangement of cortical areas, particularly between rodents and primates. Hemispheric variability and bilateral asymmetry are most pronounced in humans, which we evaluated using a high-quality multimodal parcellation of hundreds of individuals. Asymmetries include modest differences in areal size but not in areal identity. Analyses of cortical connectivity using anatomical tracers reveal highly distributed connectivity and a wide range of connection weights in monkeys and mice; indirect measures using functional MRI suggest a similar pattern in humans. Altogether, a multifaceted but integrated approach to exploring cortical organization in primate and nonprimate species provides complementary advantages and perspectives.
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Registered trials
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