ArticleCancer immunology research2020
High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed, 189 citations in OpenAlex.
- Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial.Nature medicine · 2021Trial
- Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma.Cell reports. Medicine · 2020Trial
- Toward next-generation therapeutic HPV vaccines: A review on expanding the antigen repertoire and an integrated bioinformatics selection framework.Human vaccines & immunotherapeutics · 2026Review
- Technical review of artificial intelligence in TCR-T therapy.Journal of the National Cancer Center · 2026Review
- AI-driven neoantigen identification: a comprehensive review from somatic variant calling to T cell recognition.Journal of translational medicine · 2026Review
- The critical role of artificial intelligence and bioinformatics in accelerating peptide-based vaccine discovery for tackling global infectious diseases.Briefings in bioinformatics · 2026Review
- Automating neoantigen selection for personalized cancer vaccine design.medRxiv : the preprint server for health sciences · 2026Article
- Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy.Nature communications · 2026Article
- Endogenous neoantigen-specific antibodies mediate antitumor responses and determine vaccine efficacy.Journal for immunotherapy of cancer · 2026Article
- Cytokine-driven immunogenicity prediction: integrating HLA binding and cytokine induction.Briefings in bioinformatics · 2026Article
- Neoantigen Targeting as a Novel Approach for Therapy-Resistant Tumors.Molecular diagnosis & therapy · 2026Review
- Vaccine strategies for cancer prevention in Lynch syndrome: the potential of dendritic cell-based therapy.Familial cancer · 2026Review
- Healthy donor T cell receptors expand functional neoantigen recognition beyond patient vaccination.Science advances · 2026Article
- Tumor Microenvironment in Neuroblastoma and Immunotherapeutic Approaches: Towards More Effective Treatment.Cancers · 2026Review
- Integration of Short- and Long-Read RNA Sequencing Enables the Discovery of Circular RNAs.Cancer research · 2026Article
- Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer.Cancer discovery · 2026Article
- AI-powered mapping of tumor immunity for optimized mRNA vaccine engineering.Frontiers in oncology · 2026Review
- Quantum medicine: A quantum-mechanical framework for redox biology, disease and precision medicine.Clinical and translational medicine · 2026Review
- T-SCAPE: T cell immunogenicity scoring via cross-domain aided predictive engine.Science advances · 2025Article
- High-throughput screening for class I peptide MHC binding via yeast surface display.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Xiaoshan M Shao *Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
Rohit Bhattacharya *Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-0555-9714
Justin Huang *Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
I K Ashok Sivakumar *Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-5645-9270
Collin TokheimInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
Lily ZhengInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-2722-3522
Dylan HirschInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
Benjamin KaminowInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
Ashton OmdahlInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0001-5617-9589
Maria BonsackImmunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-2087-7451
Angelika B RiemerImmunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-5865-0714
Victor E VelculescuInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-1195-438X
Valsamo AnagnostouThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kymberleigh A PagelInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland.
Rachel KarchinInstitute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland. karchin@jhu.edu.
Johns Hopkins University · USGerman Cancer Research Center · DE
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MBIOMEDICAL ENGINEERING TRAINING PROGRAMT32GM007057 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, KARCHIN, RACHEL · 1985 to 2023
$10.4MLarge-Scale Genetic Analyses of Human CancerR01CA121113 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANAGNOSTOU, VALSAMO, VELCULESCU, VICTOR E. · 2006 to 2022
$4.3MECOG-ACRIN Thoracic Malignancies Integrated Translational Science CenterU10CA180950 · NCI · EMORY UNIVERSITY · PI RAMALINGAM, SURESH S · 2014 to 2018
$2.9MPre-Doctoral Training Program in Computational MedicineT32GM119998 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2017 to 2021
$1.5MNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA121113NCI NIH HHS U10 CA180950NIGMS NIH HHS T32 GM007057NIGMS NIH HHS T32 GM119998
Abstract
Computational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins can be used to predict patient response to cancer immunotherapy. Current neoantigen predictors focus on
Indexed as
Neural Networks, ComputerAlgorithmsAntigens, NeoplasmArtificial IntelligenceCancer VaccinesCD8-Positive T-LymphocytesComputational BiologyData MiningHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansMutation, MissenseNeoplasmsPredictive Value of TestsProtein BindingSoftwareAntigens, NeoplasmCancer VaccinesHistocompatibility Antigens Class IHistocompatibility Antigens Class II
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.