Evidence map›Paper›PMID 31871111›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

FOXA1 Protein Expression in ER

Ting-Yuan David Cheng, Song Yao, Angela R Omilian, Thaer Khoury, Matthew F Buas, Rochelle Payne-Ondracek, Sirinapa Sribenja, Wiam Bshara, Chi-Chen Hong, Elisa V Bandera and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ting-Yuan David ChengDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, Florida. tingyuan.cheng@ufl.edu.ORCID 0000-0002-4105-828X
Song YaoDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Angela R OmilianDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Thaer KhouryDepartment of Pathology & Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Matthew F BuasDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Rochelle Payne-OndracekDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Sirinapa SribenjaDepartment of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID 0000-0003-0037-5884
Wiam BsharaDepartment of Pathology & Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Chi-Chen HongDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Elisa V BanderaCancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, New Jersey.
Warren DavisDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID 0000-0002-8700-5693
Michael J HigginsDepartment of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID 0000-0003-1717-9943
Roswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Reproduction, Lactation and Hormonal Factors in Breast Cancer SubtypesP01CA151135 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., OLSHAN, ANDREW · 2011 to 2017
$18.1M
Obesity, related comorbidities, and breast cancer outcomes in African AmericansR01CA185623 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI BANDERA, ELISA V, DEMISSIE, KITAW · 2014 to 2018
$6.2M
Race &Risk Factors for Early/Aggressive Breast CancerR01CA100598 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B. · 2004 to 2008
$4.8M
DNA Methylation: a Mechanism for Aggressive Breast Cancer in African-American WomR01CA133264 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., DEMISSIE, KITAW · 2010 to 2013
$3.6M
Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level.R01CA225947 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., HIGGINS, MICHAEL JOSEPH · 2019 to 2023
$3.2M
mTOR pathway in breast cancer subtypes by race: A molecular pathological studyK07CA201334 · NCI · UNIVERSITY OF FLORIDA · PI CHENG, TING-YUAN · 2016 to 2020
$693k
Obesity in ovarian cancer prognosisK22CA138563 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BANDERA, ELISA V · 2010 to 2012
$605k
NCI NIH HHS HHSN261201300021CNCI NIH HHS K07 CA201334NCI NIH HHS K22 CA138563NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA100598NCI NIH HHS R01 CA133264NCI NIH HHS R01 CA185623NCI NIH HHS R01 CA225947
6 · The paper itself

Abstract

backgroundForkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor-negative (ER

methodsWe performed IHC for FOXA1 in breast tumors (

resultsER-positive (ER

conclusionsIn this tumor-based study, higher parity was associated with lower FOXA1 expression in ER IMPACT: These findings contribute to our understanding of FOXA1 methylation and breast cancer etiology.

Indexed as

ParityAdultBlack or African AmericanBreastBreast FeedingBreast NeoplasmsCase-Control StudiesDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHumansImmunohistochemistryMiddle AgedReceptors, EstrogenFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaReceptors, Estrogen

Identifiers

PMID31871111
PMCPMC7007352
OpenAlexW2997727933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.