Evidence map›Paper›PMID 31871098›Full record

ArticleInfection and immunity2020

B Cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis.

Samuel Okurut, David B Meya, Freddie Bwanga, Joseph Olobo, Michael A Eller, Fatim Cham-Jallow, Paul R Bohjanen, Harsh Pratap, Brent E Palmer, Katharine H Hullsiek and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecular Diagnostics ofDiseases (Basel, Switzerland) · 2024
    Review
  5. Cryptococcal meningitis.Nature reviews. Disease primers · 2023
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Samuel OkurutResearch Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda okuruts@gmail.com.ORCID 0000-0002-9292-8687
David B MeyaResearch Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Freddie BwangaDepartment of Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Joseph OloboDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Michael A EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Fatim Cham-JallowLaboratory Department, Makerere University Walter Reed Project, Kampala, Uganda.
Paul R BohjanenDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Harsh PratapMucosal and Vaccine Research Program Colorado, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Brent E PalmerMucosal and Vaccine Research Program Colorado, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Katharine H HullsiekDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Yukari C ManabeResearch Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
David R BoulwareDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Edward N JanoffMucosal and Vaccine Research Program Colorado, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
University of Minnesota · USHenry M. Jackson Foundation · USMakerere University · UGUniversity of Colorado Denver · USDenver VA Medical Center · USJohns Hopkins University · USMakerere University Walter Reed Project · UG

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
Trial for the Optimal Timing of HIV Therapy after Cryptococcal MeningitisU01AI089244 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R · 2010 to 2014
$7.6M
HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
Mechanisms of Impaired HIV-associated B cell and Pneumococcal Vaccine responsesR01AI108479 · NIAID · UNIVERSITY OF COLORADO DENVER · PI JANOFF, EDWARD N · 2014 to 2018
$2.3M
Improving Outcomes of HIV-Associated Cryptococcosis in Resource-Limited SettingsK01TW010268 · FIC · UNIVERSITY OF MINNESOTA · PI RHEIN, JOSHUA R · 2016 to 2020
$703k
CSRD VA I01 CX001464FIC NIH HHS D43 TW009771FIC NIH HHS K01 TW010268NIAID NIH HHS R01 AI108479NIAID NIH HHS U01 AI089244NINDS NIH HHS R01 NS086312
6 · The paper itself

Abstract

Activated B cells modulate infection by differentiating into pathogen-specific antibody-producing effector plasmablasts/plasma cells, memory cells, and immune regulatory B cells. In this context, the B cell phenotypes that infiltrate the central nervous system during human immunodeficiency virus (HIV) and cryptococcal meningitis coinfection are ill defined. We characterized clinical parameters, mortality, and B cell phenotypes in blood and cerebrospinal fluid (CSF) by flow cytometry in HIV-infected adults with cryptococcal (

Indexed as

AdultB-LymphocytesCase-Control StudiesCell CompartmentationCerebrospinal FluidCoinfectionFemaleHIV InfectionsHumansMaleMeningitis, CryptococcalMiddle AgedViral LoadactivationB cell activationB cell subsetsbloodcerebrospinal fluidcryptococcal meningitisHIVHIV coinfectionPD-1PD-1 expressionplasmablasts/plasma cellssurvival

Identifiers

PMID31871098
PMCPMC7035924
OpenAlexW2996987179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.