Evidence map›Paper›PMID 31871096›Full record

ArticleInfection and immunity2020

Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract.

D E Kunkle, T F Bina, X R Bina, J E Bina

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Emergence of theMicrobiology spectrum · 2023
    Article
  4. Review
  5. Article
  6. Ecological diversification reveals routes of pathogen emergence in endemicProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Article
  8. Assessment and Antibiotic Resistance Profiling inAntibiotics (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

D E KunkleDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
T F BinaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
X R BinaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
J E BinaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA jbina@pitt.edu.
University of Pittsburgh · US

Funding

Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
Environmental adaptation by Vibrio choleraeR01AI132460 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAMES Edward BINA · 2018 to 2026
$3.2M
Function of the Vibrio cholerae RND efflux systemsR21AI141934 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BINA, JAMES EDWARD · 2019 to 2020
$413k
NIAID NIH HHS R01 AI132460NIAID NIH HHS R21 AI141934NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

Multidrug efflux systems belonging to the resistance-nodulation-division (RND) superfamily are ubiquitous in Gram-negative bacteria. RND efflux systems are often associated with multiple antimicrobial resistance and also contribute to the expression of diverse bacterial phenotypes including virulence, as documented in the intestinal pathogen

Indexed as

Gene Expression Regulation, BacterialVirulence FactorsBacterial ProteinsDNA-Binding ProteinsGastrointestinal TractHumansIntercalating AgentsTranscription FactorsVibrio choleraeVirulenceBacterial ProteinsDNA-Binding ProteinsIntercalating AgentstoxR protein, Vibrio choleraeTranscription FactorsVirulence FactorscholeraOmpRtwo-component regulatory systemsvirulence regulation

Identifiers

PMID31871096
PMCPMC7035920
OpenAlexW2995762884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.