Evidence map›Paper›PMID 31871093›Full record

ArticleAntimicrobial agents and chemotherapy2020

Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis.

Henrik Bjugård Nyberg, Heather R Draper, Anthony J Garcia-Prats, Stephanie Thee, Adrie Bekker, Heather J Zar, Andrew C Hooker, H Simon Schaaf, Helen McIlleron, Anneke C Hesseling and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Henrik Bjugård NybergDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2249-7911
Heather R DraperDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Anthony J Garcia-PratsDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-9280-1950
Stephanie TheeDepartment of Pediatrics, Division of Pneumonology, Immunology and Intensive Care, Charité University Medicine, Berlin, Germany.
Adrie BekkerDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Andrew C HookerDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
H Simon SchaafDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Helen McIlleronDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Anneke C HesselingDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Paolo DentiDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa paolo.denti@uct.ac.za.ORCID 0000-0001-7494-079X
Desmond Tutu HIV Foundation · ZAUniversity of Cape Town · ZAUppsala University · SECharité - Universitätsmedizin Berlin · DE

Funding

PHARMACOKINETICS AND TOXICITY OF SECONDLINE ANTITUBERCULOSIS DRUGS IN HIV-INFECTER01HD069169 · NICHD · STELLENBOSCH UNIVERSITY · PI HESSELING, ANNEKE CATHARINA · 2011 to 2015
$2.0M
Optimal dosing of 1st line antituberculosis and antiretroviral drugs in childrenR01HD069175 · NICHD · UNIVERSITY OF CAPE TOWN · PI MCILLERON, HELEN · 2011 to 2018
$1.8M
NICHD NIH HHS R01 HD069169NICHD NIH HHS R01 HD069175Wellcome Trust 206379/Z/17/Z
6 · The paper itself

Abstract

Ethionamide has proven efficacy against both drug-susceptible and some drug-resistant strains of

Indexed as

AdolescentAntitubercular AgentsChildChild, PreschoolDrug Resistance, Multiple, BacterialEthionamideFemaleHumansInfantMaleRifampinAntitubercular AgentsEthionamideRifampinethionamidemultidrug resistancepediatric infectious diseasepopulation pharmacokineticstuberculosis

Identifiers

PMID31871093
PMCPMC7038277
OpenAlexW2995868755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.