Evidence map›Paper›PMID 31871087›Full record

ArticleAntimicrobial agents and chemotherapy2020

β-Lactamase of Mycobacterium tuberculosis Shows Dynamics in the Active Site That Increase upon Inhibitor Binding.

Wouter Elings, Anamika Gaur, Anneloes J Blok, Monika Timmer, Hugo van Ingen, Marcellus Ubbink

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Mechanisms of ligand binding.Biophysics reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wouter ElingsLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.ORCID 0000-0003-0304-2874
Anamika GaurLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.ORCID 0000-0003-4981-8279
Anneloes J BlokLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Monika TimmerLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Hugo van IngenLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.ORCID 0000-0002-0808-3811
Marcellus UbbinkLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands m.ubbink@chem.leidenuniv.nl.ORCID 0000-0002-2615-6914
Leiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

Azabicyclo Compoundsbeta-LactamasesBoronic AcidsCatalytic DomainClavulanic AcidMagnetic Resonance SpectroscopyMycobacterium tuberculosisProtein BindingavibactamAzabicyclo Compoundsbeta-LactamasesBoronic AcidsClavulanic Acidavibactambeta-lactamasesBlaCchemical exchangeclavulanic acidinhibitionNMR spectroscopystructural biology

Identifiers

PMID31871087
PMCPMC7038250
OpenAlexW2997668074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.