ArticleAntimicrobial agents and chemotherapy2020
A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques.
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Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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0cells of the map it votes in
47citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 62 citations in OpenAlex.
- Pediatric NIH Workshop: Session I: Nonhuman Primate Models in HIV Prevention Research-A Historical and Comparative Perspective.Journal of medical primatology · 2026Review
- Impact of Tenofovir Alafenamide Sub-Dermal Implant Insertion Site Scarring on Acceptability and HIV Prevention Preferences: A Prospective Cohort Study in Durban, South Africa.Journal of the International AIDS Society · 2026Observational
- Localized inflammasome inhibition mitigates foreign body response to subcutaneous long-acting antiretroviral therapy for HIV.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- An ultra-long-acting dimeric bictegravir prodrug defined by a short pharmacokinetic tail.Nature communications · 2026Article
- Review
- A scalable ultra-long-acting tenofovir phosphonate prodrug sustains HBV suppression.Science advances · 2025Article
- The effect of the foreign body response on drug elution from subdermal delivery systems.Biomaterials · 2025Article
- Review
- Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Recent Advances in Antiviral Drug Delivery Strategies.AAPS PharmSciTech · 2025Review
- Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drug.Data in brief · 2025Article
- Ultra-Long-Term Delivery of Hydrophilic Drugs Using InjectablebioRxiv : the preprint server for biology · 2024Article
- Antiviral potency of long-acting islatravir subdermal implant in SHIV-infected macaques.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Polymer Delivery Systems for Long-Acting Antiretroviral Drugs.Pharmaceutics · 2024Review
- Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques.Pharmaceutics · 2023Article
- Chronic Hepatitis B Infection: New Approaches towards Cure.Biomolecules · 2023Review
- Changes in local tissue microenvironment in response to subcutaneous long-acting delivery of tenofovir alafenamide in rats and non-human primates.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles.Biomaterials science · 2023Article
- Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats.Nature communications · 2022Article
- An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression.Science advances · 2022Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Jonathan T Su *Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Solange M Simpson *Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Samuel SungDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Ewa Bryndza TfailyDepartment of Cell and Molecular Biology, Northwestern University, Chicago, Illinois, USA.
Ronald VeazeyDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Mark MarzinkeDivision of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiang QiuDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
David WatrousDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Lakmini WidanapathiranaDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Elizabeth PearsonDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
M Melissa PeetCONRAD, Contraceptive Research and Development, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, Virginia, USA.
Dipu KarunakaranDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Brooke GraspergeDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Georgina DobekTulane University School of Medicine, New Orleans, Louisiana, USA.
Charlette M CainFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Thomas HopeDepartment of Cell and Molecular Biology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-7183-8319
Patrick F KiserDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA patrick.kiser@northwestern.edu.ORCID 0000-0002-3868-7122
Northwestern University · USTulane University · USEastern Virginia Medical School · USJohns Hopkins University · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MVaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MSustained Long Acting Prevention Against HIV Program OperationUM1AI120184 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOPE, THOMAS, KISER, PATRICK FRANKLIN · 2015 to 2019
$17.9MNIAID NIH HHS P30 AI094189NIAID NIH HHS UM1 AI120184NIH HHS P51 OD011104
Abstract
We describe the
Indexed as
Delayed-Action PreparationsAdenineAlanineAnimalsAnti-HIV AgentsDrug ImplantsFemaleFumaratesHIV InfectionsHumansInflammationMacaca mulattaMaleNecrosisPolyurethanesRabbitsAdenineAlanineAnti-HIV AgentsDelayed-Action PreparationsDrug ImplantsFumaratesPolyurethanesTecoflexTenofovirtenofovir alafenamideantiretroviral agentshistopathologyimplantpreexposure prophylaxis
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.