Evidence map›Paper›PMID 31871052›Full record

ArticleThe Journal of biological chemistry2020

Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1.

Victoria Casado-Medrano, Laura Barrio-Real, Laura Gutiérrez-Miranda, Rogelio González-Sarmiento, Eladio A Velasco, Marcelo G Kazanietz, María J Caloca

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer.Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Victoria Casado-MedranoInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.ORCID 0000-0002-6929-4559
Laura Barrio-RealMolecular Medicine Unit and Institute of Molecular and Cellular Biology of Cancer, Biomedical Research Institute of Salamanca, University of Salamanca, 37007 Salamanca, Spain.
Laura Gutiérrez-MirandaInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.
Rogelio González-SarmientoMolecular Medicine Unit and Institute of Molecular and Cellular Biology of Cancer, Biomedical Research Institute of Salamanca, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-2726-6795
Eladio A VelascoInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.ORCID 0000-0002-9682-5589
Marcelo G KazanietzDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
María J CalocaInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain mj.caloca@csic.es.ORCID 0000-0002-1003-2685
Universidad de Valladolid · ESUniversidad de Salamanca · ESTranslational Therapeutics (United States) · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Protein kinase C and lung carcinogenesisR01ES026023 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2015 to 2019
$2.3M
Effectors of protein kinase C-mediated tumor progressionR01CA196232 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2016 to 2022
$2.0M
CXCL13: a mediator of prostate cancer progressionR01CA189765 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA189765NCI NIH HHS R01 CA196232NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES026023
6 · The paper itself

Abstract

β1-chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the

Indexed as

Alternative SplicingAmino Acid MotifsAnimalsCell CycleCell Line, TumorCell NucleusChimerin ProteinsChlorocebus aethiopsCOS CellsDiglyceridesExonsGene SilencingHumansProtein DomainsProtein Isoformsrac1 GTP-Binding Proteinchimaerin-beta3 protein, humanChimerin ProteinsDiglyceridesProtein Isoformsrac1 GTP-Binding ProteinRAC1 protein, humanRNA, Small Interferingcell cyclecell signalingGTPase-activating protein (GAP)nuclear export signal (NES)nuclear localizationnuclear localization signal (NLS)nucleusRac (Rac GTPase)splicingβ1-chimaerin

Identifiers

PMID31871052
PMCPMC6996883
OpenAlexW2997080129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.