ArticleNeuroscience letters2020
Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice.
Article in Neuroscience letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration.Frontiers in aging neuroscience · 2021Pooled it
- Assessing hearing and hearing loss in mice with open-source system and auditory brainstem response (OpenSABR).Journal of neurophysiology · 2026Article
- Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease.Scientific reports · 2026Article
- Differences in hearing across the lifespan in two strains of Alzheimer's mouse models as measured using behavioral and physiological techniques.Hearing research · 2026Article
- An open-source deep learning-based toolbox for automated auditory brainstem response analyses (ABRA).Scientific reports · 2026Article
- Abnormal Hearing Phenotypes in "Ignorome" Knockout Mice as Predictors of Cognitive Dysfunction.Genes, brain, and behavior · 2026Article
- Dementia and hearing loss: from risk to mechanisms and management.Frontiers in dementia · 2026Review
- An open-source system for recording the auditory brainstem response (ABR) and an example application in mice with hearing loss.bioRxiv : the preprint server for biology · 2025Article
- Serum Albumin/Globulin Ratio and Cognitive Function in Americans: A Linear Association.Brain and behavior · 2025Article
- An Open-Source Deep Learning-Based Toolbox for Automated Auditory Brainstem Response Analyses (ABRA).bioRxiv : the preprint server for biology · 2025Article
- 5xFAD mutations induce hearing impairment in the Ahl-corrected 5xFAD mice.Experimental neurology · 2025Article
- Early detection of Alzheimer's disease using the MEMORIES mnemonic.Chronic diseases and translational medicine · 2025Review
- Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease.JASA express letters · 2024Article
- Hearing loss promotes Alzheimer's disease.Nature aging · 2024Article
- GDF1 ameliorates cognitive impairment induced by hearing loss.Nature aging · 2024Article
- Sex and race differences in the association of albumin with cognitive function in older adults.Brain and behavior · 2024Article
- Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea.Aging biology · 2024Article
- Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.PloS one · 2024Article
- Sensorineural hearing loss and cognitive impairment: three hypotheses.Frontiers in aging neuroscience · 2024Review
- Sensory processing deficits and related cortical pathological changes in Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive loss of memory and cognitive decline. Over the last decade, it has been found that defects in sensory systems could be highly associated with AD. Hearing is an important neural sense. However, little is known about hearing functional changes in AD. In this study, APP/PS1 AD mice (Jackson Lab: Stack No. 004462) were used. Hearing function was assessed by auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE), and cochlear microphonics (CM) recordings. Wild-type (WT) littermates served as control. We found that APP/PS1 AD mice measured as ABR threshold had hearing loss. The hearing loss appeared at high frequency as early as 2 months old, prior to the reported occurrence of spatial learning deficit at 6-7 months of age in this AD mouse model. The hearing loss was progressive and extended from high frequency to low frequency. At 3-4 months old, the hearing loss appeared in the whole-frequency range. Moreover, the wave IV and V in the super-threshold ABR were eliminated, indicating substantial impairment in inferior colliculus, nuclei of lateral lemniscus, and medial geniculate body in the upper brainstem. DPOAE in APP/PS1 AD mice was also reduced. However, there was no reduction in CM in APP/PS1 mice. These data demonstrate that unlike age-related hearing loss APP/PS1 AD mice have early onset of hearing loss. These data also suggest that hearing function testing could provide a simple, sensitive, non-invasive screen-tool for early detecting AD and localizing lesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.