ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017.
Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Sequence Types ofPathogens (Basel, Switzerland) · 2026Article
- InFuture microbiology · 2025Article
- Clinical-imaging diversity of exudative pulmonary cryptococcosis with different immune states.Scientific reports · 2025Article
- Multi-Locus Sequence Typing-Based Genetic Analysis, Antifungal Resistance, and Clinical Prognosis of Cryptococcus neoformans Infections in HIV-Infected Patients in Northern China.The American journal of tropical medicine and hygiene · 2024Article
- Clinical imaging diagnosis of pulmonary cryptococcosis with different therapeutic responses.Scientific reports · 2024Article
- Genotyping Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Global Analyses of Multi-Locus Sequence Typing Data Reveal Geographic Differentiation, Hybridization, and Recombination in theJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Pulmonary cryptococcosis misdiagnosed as lung cancer in a man with normal immune function: A case report.Radiology case reports · 2022Article
- Molecular epidemiology and microbiological characteristics of Cryptococcus gattii VGII isolates from China.PLoS neglected tropical diseases · 2022Article
- Performance of the Colloidal Gold Immunochromatography of Cryptococcal Antigen on Bronchoalveolar Lavage Fluid for the Diagnosis of Pulmonary Cryptococcosis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Molecular Epidemiology and Antifungal Resistance ofFrontiers in microbiology · 2022Article
- Antifungal susceptibility and molecular characteristics ofFrontiers in microbiology · 2022Article
- Clinical features of cryptococcosis in patients with different immune statuses: a multicenter study in Jiangsu Province-China.BMC infectious diseases · 2021Article
- Clinical characteristics,The Journal of international medical research · 2021Article
- Associations betweenJournal of fungi (Basel, Switzerland) · 2021Review
- Article
- CryptoType - Public Datasets for MALDI-TOF-MS Based Differentiation ofFrontiers in cellular and infection microbiology · 2021Article
- Multi-locus Sequence Typing and Whole Genome Sequence Analysis of Cryptococcus neoformans Isolated from Clinical Specimens in Vajira Hospital, Bangkok, Thailand.Mycopathologia · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis from 2013 to 2017 in a major teaching hospital in China.
methodsTrends in antifungal drug susceptibility of 217 consecutive non-repetitive cryptococcal isolates collected from patients of an university hospital in China were analyzed between 2013 and 2017. Of those, 98 isolates were conserved for identification by internal transcribed spacer (ITS) sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) system. Multilocus sequence typing (MLST) was used to designate molecular types. Clinical characteristics of the 98 patients with cryptococcosis during the period of 2013-2017 were retrospectively evaluated.
resultsThere was a trend for gradual increase in the MIC range of fluconazole was from 2013 to 2017. The conserved 98 clinical cryptococcal isolates included 97 C. neoformans and one C. gattii, and 90 (91.8%) isolates belonged to ST5 genotype VNI. Out of the 98 patients with cryptococcosis, 28 (28.6%) were HIV-infected and 32 (32.7%) had no underlying diseases. HIV-infected patients had higher mortality than HIV-uninfected patients (28.6% vs 14.3%, p=0.147).
conclusionsMost of the patients with cryptococcosis were not HIV-infected in this study, while patients with HIV had a higher mortality. Reduced susceptibility to fluconazole was observed among C. neoformans isolates, most of them belonged to ST5 genotype VNI having an impact on the effective dose of fluconazole.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.