Evidence map›Paper›PMID 31870744›Full record

ReviewJournal of cardiovascular computed tomography

Risk stratification of coronary plaques using physiologic characteristics by CCTA: Focus on shear stress.

Habib Samady, David S Molony, Ahmet U Coskun, Anubodh S Varshney, Bernard De Bruyne, Peter H Stone

Abstract readReview
In one paragraph

Review in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  7. Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients.American heart journal plus : cardiology research and practice · 2023
    Article
  8. The site-specific distribution of atheromatous plaques in the coronary arteries.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023
    Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Habib SamadyEmory University School of Medicine, Atlanta, GA, USA. Electronic address: hsamady@emory.edu.
David S MolonyEmory University School of Medicine, Atlanta, GA, USA.
Ahmet U CoskunBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anubodh S VarshneyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bernard De BruyneCardiovascular Center Aalst, Aalst, Belgium.
Peter H StoneBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
NHLBI NIH HHS T32 HL007604
6 · The paper itself

Abstract

The identification of factors determining whether a lesion progresses, destabilizes or becomes quiescent remains a challenge. Wall or endothelial shear stress (WSS or ESS, respectively), the frictional force acting on the lumen wall, is strongly associated with changes in the natural history of lesions. Several clinical intravascular imaging studies have shown a clear link between disturbed flow, typically characterized by low WSS, and plaque growth. In support of these studies, in-vitro experiments of shear stress have identified several mechanisms promoting atherosclerosis. More recently, the relationship between WSS and major adverse cardiac events has been explored. Improvements in coronary computed tomography angiography (CCTA) image resolution and quality has allowed for the calculation of WSS from CT. In this review, we provide an introduction to WSS, highlight important human and animal intravascular-based WSS studies, and discuss CT-based WSS studies to date. Finally, we discuss future directions of CCTA and WSS computation.

Indexed as

Computed Tomography AngiographyCoronary CirculationHemodynamicsPlaque, AtheroscleroticTomography, X-Ray ComputedAnimalsCoronary Artery DiseaseCoronary VesselsDisease ProgressionHumansMechanotransduction, CellularModels, CardiovascularPredictive Value of TestsRisk AssessmentRisk FactorsRupture, Spontaneous

Identifiers

PMID31870744
PMCPMC8749833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.