ArticleNeurobiology of aging2020
Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
- Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.Magma (New York, N.Y.) · 2026Article
- Locus coeruleus degeneration is associated with orthostatic hypotension in Parkinson's disease and multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function.Brain communications · 2026Article
- Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.Neurobiology of aging · 2026Article
- Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry.Alzheimer's research & therapy · 2025Article
- Nigral volume loss in prodromal, early, and moderate Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Microstructural assessment of the locus coeruleus-entorhinal cortex pathway and association with ATN markers in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance.Scientific reports · 2024Article
- Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis.Brain imaging and behavior · 2024Article
- Association of emotional and behavioral problems with the development of the substantia nigra, subthalamic nucleus, and red nucleus volumes and asymmetries from childhood to adolescence: A longitudinal cohort study.Translational psychiatry · 2024Article
- Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease.Translational neurodegeneration · 2024Article
- A predictor-informed multi-subject bayesian approach for dynamic functional connectivity.PloS one · 2024Article
- Assessing the Role of Locus Coeruleus Degeneration in Essential Tremor and Parkinson's Disease with Sleep Disorders.Journal of Parkinson's disease · 2024Article
- Regional age-related changes of neuromelanin and iron in the substantia nigra based on neuromelanin accumulation and iron deposition.European radiology · 2023Article
- Article
- State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities.Neuroscience and biobehavioral reviews · 2023Review
- In vivo tractography of human locus coeruleus-relation to 7T resting state fMRI, psychological measures and single subject validity.Molecular psychiatry · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young and older adult cohorts, as well as their relationship with cognition. In LC, the older cohort exhibited a significant reduction in mean and radial diffusivity, but a significant increase in fractional anisotropy compared with the young cohort. We observed a significant correlation between the decrease in LC mean, axial, and radial diffusivities and measures examining cognition (Rey Auditory Verbal Learning Test delayed recall) in the older adult cohort. This observation suggests that LC is involved in retaining cognitive abilities. In addition, we observed that iron deposition in SNpc occurs early in life and continues during normal aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.