ArticleLipids in health and disease2019
Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The impact of sex hormones and sex chromosomes on the HDL anti-inflammatory capacity in transgender individuals.Journal of lipid research · 2026Article
- Is endothelial dysfunction induced by aromatase inhibitors reversible after treatment?Breast cancer research and treatment · 2026Article
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- Comparative effects of dietary pomegranate peel andFrontiers in nutrition · 2026Article
- Serum vitamin C associated with lipids levels in children and adolescents: a national cross-sectional study.Nutrition & metabolism · 2025Article
- Mistimed Feeding Disrupts Metabolic Rhythm and Increases Lipid Accumulation of Growing Rabbits in Winter.Animals : an open access journal from MDPI · 2025Article
- Blocking HJournal of molecular medicine (Berlin, Germany) · 2024Article
- Enhanced atherosclerosis in apolipoprotein E knockout rabbits: role of apoB48-rich remnant lipoproteins.Frontiers in cardiovascular medicine · 2024Article
- New Gene Markers of Exosomal Regulation Are Involved in Porcine Granulosa Cell Adhesion, Migration, and Proliferation.International journal of molecular sciences · 2023Article
- Urotensin II Enhances Advanced Aortic Atherosclerosis Formation and Delays Plaque Regression in Hyperlipidemic Rabbits.International journal of molecular sciences · 2023Article
- Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundEndothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits.
methodsMale rabbits were under orchiectomy whereas female rabbits were under ovariectomy. We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet.
resultsOn a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. On a cholesterol diet; however, male Tg rabbits but not female Tg rabbits showed significant resistance to diet-induced hypercholesterolemia and atherosclerosis. The EL-mediated atheroprotective effect was eliminated after orchiectomy in male Tg rabbits. Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis.
conclusionThese results suggest that increased EL protects against diet-induced hypercholesterolemia and atherosclerosis. The beneficial effect of EL was dependent upon the presence of androgenic hormones.
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