ArticleBMC pulmonary medicine2019
Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children.
Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration.Journal of Korean medical science · 2022Pooled it
- A comparative assessment of subchronic inhalation health risks between peracetic acid and chlorine dioxide in SPF pigs maintained in barrier environments.BMC veterinary research · 2026Article
- Childhood Interstitial Lung Disease (chILD) Associated With Toxic Chemical Inhalation Exposures: A State-of-the-Art Review.Pediatric pulmonology · 2025Review
- Evaluating Metabolic Signatures in the Serum of South Korean Patients with Humidifier Disinfectant-Associated Lung Injury Identified through Untargeted Metabolomics.Environmental health perspectives · 2025Article
- Article
- 3D Printed SERS-Active Thin-Film Substrates Used to Quantify Levels of the Genotoxic Isothiazolinone.ACS omega · 2022Article
- Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay.Toxicological research · 2022Article
- Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns.Nanomaterials (Basel, Switzerland) · 2021Article
- Fibrosis as a result of polyhexamethylene guanide exposure in cultured Statens Seruminstitut Rabbit Cornea (SIRC) cells.Environmental analysis, health and toxicology · 2021Article
- The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children.Clinical and experimental pediatrics · 2020Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundUse of humidifier disinfectants (HD) at home leads to chemical airborne exposure, causing HD associated lung injury (HDLI) with high mortality. However, the lung function in children diagnosed with HDLI is not well studied. We investigated the effect of HD exposure on lung function, prognosis, and exposure characteristics associated with the lung function phenotype in children.
methodsEighty-one children diagnosed with HDLI in a nationwide cohort were tested for spirometry and diffusing capacity of the lung for carbon monoxide (DLco) from July 2013 and followed up with at five time points over 2 years. The results were compared with 122 children without HD exposure as controls. Home investigation and questionnaire analysis were conducted to assess HD inhalation exposure.
resultsHDLI survivor's mean percent of predicted forced expiratory volume in 1 s (FEV
conclusionsHD exposure affects prolonged decrement in lung function, especially DLco, particularly among children who are exposed within the first year of life. These results suggested that early-life HD exposure determines long-term prognosis of lung function in children.
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Registered trials
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