Evidence map›Paper›PMID 31870338›Full record

Trial reportBMC pediatrics2019

Impact of sunflower seed oil versus mustard seed oil on skin barrier function in newborns: a community-based, cluster-randomized trial.

Aimee Summers, Marty O Visscher, Subarna K Khatry, Jeevan B Sherchand, Steven C LeClerq, Joanne Katz, James M Tielsch, Luke C Mullany

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01177111 (Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01177111 phase3completednot on this map

Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2010 to 2017Enrolled29,260ConditionsNeonatal Mortality, Neonatal SepsisArmsSunflower seed oil, Mustard seed oil
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Topical emollient for preventing infection in preterm infants.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Neonatal sepsis and the skin microbiome.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Aimee SummersDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W5009, Baltimore, MD, 21205, USA.
Marty O VisscherSkin Sciences Program, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Subarna K KhatryDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W5009, Baltimore, MD, 21205, USA.
Jeevan B SherchandDepartment of Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj Rd, Kathmandu, 44600, Nepal.
Steven C LeClerqDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W5009, Baltimore, MD, 21205, USA.
Joanne KatzDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W5009, Baltimore, MD, 21205, USA.
James M TielschDepartment of Global Health, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Avenue, Washington, DC, USA.
Luke C MullanyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W5009, Baltimore, MD, 21205, USA. lmullany@jhu.edu.ORCID 0000-0003-4668-9803
Johns Hopkins University · USCincinnati Children's Hospital Medical Center · USMilken Institute · USTribhuvan University Teaching Hospital · NP

Funding

Impact of Sunflower Oil Massage on Neonatal Mortality in NepalR01HD060712 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MULLANY, LUKE C · 2009 to 2013
$2.9M
National Institute of Child Health and Human Development HD060712NICHD NIH HHS R01 HD060712
6 · The paper itself

Abstract

backgroundNatural vegetable oils are widely used for newborn massage in many low resource settings. Animal models indicated that sunflower seed oil (SSO) can accelerate skin barrier recovery following damage, while other oils, including mustard oil (MO), may cause further skin barrier damage. The objective was to compare the effects of two SSO and MO used for routine massage on skin integrity in premature and full-term neonates.

methodsThis community-based cluster randomized controlled trial included 995 neonates assigned to full body massage with sunflower seed oil (SSO, intervention) or mustard seed oil (MO, standard practice) from July 2012-May 2014 in Sarlahi, Nepal. Skin integrity measures were evaluated over 28 days, including skin condition (erythema, rash, dryness), skin surface pH, stratum corneum (SC) cohesion/protein concentration, and transepidermal water loss (TEWL). Overall means and rates of change in these skin measures were compared between oil groups using bivariate random-effects models.

results500 and 495 live born neonates received repeated massage with MO and SSO, respectively. Skin pH decreased more quickly for SSO than MO in the first week of life, with a difference in mean daily reductions of 0.02 (95% CI: 0.002-0.040). Erythema, rash and dryness increased (worsened) over days 1-14 then decreased by day 28, with no significant oil group differences. TEWL increased over time, with no significant oil group differences. Gestational age did not modify the effect; the slightly faster decrease in skin pH among SSO infants was similar in magnitude between term and preterm infants.

conclusionsOil type may contribute to differences in skin integrity when neonates are massaged regularly. The more rapid acid mantle development observed for SSO may be protective for neonates in lower resource settings.

trial registrationClinicalTrials.gov (NCT01177111); registered August 6th, 2010.

Indexed as

MassageFemaleHumansInfant, NewbornInfant, PrematureMaleMustard PlantPlant OilsSkin Physiological PhenomenaSunflower Oilmustard oilPlant OilsSunflower OilEmollient therapyMassageMustard oilNeonatepHSkinSkin barrierSkin conditionStratum corneumSunflower oilTEWL

Identifiers

PMID31870338
PMCPMC6927111
OpenAlexW2995394609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.