Evidence map›Paper›PMID 31870105›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2019

Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study.

Takao Asai, Yasuo Tsuchiya, Kumudesh Mishra, Anu Behari, Pooja Shukla, Toshikazu Ikoma, Vinay K Kapoor, Kazutoshi Nakamura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. How I Manage My Patients with Gall Bladder Cancer?Indian journal of surgical oncology · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takao Asai1Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Niigata, Japan.ORCID 0000-0002-3536-5072
Yasuo TsuchiyaDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Kumudesh MishraDepartment of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014 Uttar Pradesh, India.
Anu BehariDepartment of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014 Uttar Pradesh, India.
Pooja ShuklaDepartment of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014 Uttar Pradesh, India.
Toshikazu IkomaDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Vinay K KapoorDepartment of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014 Uttar Pradesh, India.
Kazutoshi NakamuraDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Niigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarcinogen metabolism pathway and tumor suppressor gene polymorphisms have been reported to be associated with increased gallbladder cancer risk. However, the association of genetic variants and gallbladder cancer risk in Indians are not well studied. We examined whether genetic polymorphisms of metabolic enzymes cytochrome P450 1A1 and glutathione S-transferase and tumor suppressor gene p53 (TP53) are associated with an increased risk of gallbladder cancer in North Indians.

methodsThis hospital-based case-control study was conducted in 96 gallbladder cancer patients with gallstones (cases) and 93 cholelithiasis patients (controls) at the Sanjay Gandhi Postgraduate Institute of Medical Sciences in Lucknow, India from July 2014 through May 2017. Genomic DNA was extracted from white blood cells of each patient using a simple salting-out procedure. The genotypic frequencies of CYP1A1 rs4646903, CYP1A1 rs1048943, and TP53 rs1042522 polymorphisms were investigated using TaqMan SNP Genotyping Assay and GSTM1 and GSTT1 polymorphisms were analyzed using the multiplex PCR assay.

resultsThe frequency of CC genotype of TP53 rs1042522 polymorphism was 27.1% (26/96) in cases and 12.9% (12/93) in controls. The CC genotype was associated with an increased risk of gallbladder cancer in North Indians (age- and sex-adjusted odds ratio, 2.81; 95% confidence interval, 1.19-6.61; P = 0.02). No significant differences in genotypic and allelic frequencies of the metabolic pathway gene polymorphisms were found between cases and controls.

conclusionsOur data provide preliminary evidence that the CC genotype of the TP53 rs1042522 polymorphism may be associated with an increased risk of gallbladder cancer in North Indians.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesCholelithiasisCytochrome P-450 CYP1A1FemaleGallbladderGallbladder NeoplasmsGallstonesGene FrequencyGenes, Tumor SuppressorGenetic Predisposition to DiseaseGlutathione TransferaseHumansIndiaCYP1A1 protein, humanCytochrome P-450 CYP1A1glutathione S-transferase T1Glutathione TransferaseTP53 protein, humanTumor Suppressor Protein p53codon 72gallbladder cancerNorth IndiansPolymorphismtumor suppressor gene

Identifiers

PMID31870105
PMCPMC7173363
OpenAlexW2997192264

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.