Evidence map›Paper›PMID 31869760›Full record

ReviewCurrent opinion in cell biology2020

Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.

Meng Zhu, Magdalena Zernicka-Goetz

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Apical PAR-3 caps orient the mitotic spindle inbioRxiv : the preprint server for biology · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Cytoskeletal control of early mammalian development.Nature reviews. Molecular cell biology · 2021
    Review
  11. Review
  12. Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Meng ZhuMammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK.
Magdalena Zernicka-GoetzMammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK. Electronic address: mz205@cam.ac.uk.

Funding

Temporal program for cell fate specification in the mouse embryoR01HD100456 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Magdalena Zernicka-Goetz · 2020 to 2026
$3.3M
NICHD NIH HHS R01 HD100456Wellcome Trust
6 · The paper itself

Abstract

Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establish cell polarization. In this review, we discuss the current understanding of cell polarity establishment, focusing on the formation of the apical domain in the mouse embryo. We will also discuss outstanding questions and possible directions for future study.

Indexed as

AnimalsCell PolarityEmbryo, MammalianMiceActomyosinApical domainDe novo cell polarity establishmentMouse embryoPar complexProtein clustering

Identifiers

PMID31869760
PMCPMC10294546

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.