Evidence map›Paper›PMID 31869588›Full record

ArticleJournal of colloid and interface science2020

Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration.

Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano, María Vallet-Regí, Chiara Vitale-Brovarone, Sonia Fiorilli

Open access · greenAbstract read
In one paragraph

Article in Journal of colloid and interface science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

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  7. New materials and complications of prostheses in humans: situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carlotta PontremoliDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, Italy. Electronic address: carlotta.pontremoli@polito.it.
Isabel Izquierdo-BarbaDepartamento de Química en Ciencias Farmacéuticas, Unidad de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12. Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain. Electronic address: ibarba@ucm.es.
Giorgia MontalbanoDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, Italy. Electronic address: giorgia.montalbano@polito.it.
María Vallet-RegíDepartamento de Química en Ciencias Farmacéuticas, Unidad de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12. Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain. Electronic address: vallet@ucm.es.
Chiara Vitale-BrovaroneDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, Italy. Electronic address: chiara.vitale@polito.it.
Sonia FiorilliDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, Italy. Electronic address: sonia.fiorilli@polito.it.
Politecnico di Torino · ITUniversidad Complutense de Madrid · ES

Funding

European Research Council 694160
6 · The paper itself

Abstract

hypothesisThe treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a radical improvement of the existing therapeutic approach through the design of advanced biomaterials combining the ability to promote bone regeneration with anti-adhesive properties able to minimise unspecific biomolecules adsorption and bacterial adhesion. Strontium-containing mesoporous bioactive glasses (Sr-MBG), which are able to exert a pro-osteogenic effect by releasing Sr EXPERIMENTS: Sr-MBG have been post-synthesis modified by co-grafting hydrolysable short chain silanes containing amino (aminopropylsilanetriol) and carboxylate (carboxyethylsilanetriol) moieties to achieve a zwitterionic zero-charge surface. The final system was then characterised in terms of textural-structural properties, bioactivity, cytotoxicity, pro-osteogenic and anti-adhesive capabilities.

findingsAfter zwitterionization the in vitro bioactivity was maintained, as well as the ability to release Sr

Indexed as

Bone RegenerationAnimalsBiocompatible MaterialsBone and BonesGlassHumansParticle SizePorosityStrontiumSurface PropertiesBiocompatible MaterialsStrontiumAnti-adhesive surfacesMesoporous Bioactive GlassesPro-osteogenicStrontium-releasing materialszwitterionic surfaces

Identifiers

PMID31869588
PMCPMC7116262
OpenAlexW2996503019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.