Evidence map›Paper›PMID 31869396›Full record

ArticlePLoS pathogens2019

Herpes simplex encephalitis in adult patients with MASP-2 deficiency.

Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  6. Innate Immune Mechanisms in the Central Nervous System.Advances in experimental medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Stéphanie BibertInfectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-5170-7506
Jocelyne PiretResearch center in Infectious Diseases, CHU of Quebec and Laval University, Quebec city, Canada.
Mathieu QuinodozDepartment of Computational Biology, Unit of Medical Genetics, University of Lausanne, Lausanne Switzerland.ORCID 0000-0002-9841-4433
Emilie CollinetInfectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.
Vincent ZoeteLudwig Institute for Cancer research, University of Lausanne, Lausanne, Switzerland.
Olivier MichielinLudwig Institute for Cancer research, University of Lausanne, Lausanne, Switzerland.
Rafik MenasriaResearch center in Infectious Diseases, CHU of Quebec and Laval University, Quebec city, Canada.
Pascal MeylanInfectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.
Titus BihlCanton Hospital of Fribourg, Fribourg, Switzerland.ORCID 0000-0001-6374-3520
Véronique ErardCanton Hospital of Fribourg, Fribourg, Switzerland.
Florence FellmannDepartment of Genetics, Laboratoire National de Santé, Dudelange, Luxembourg.
Carlo RivoltaDepartment of Computational Biology, Unit of Medical Genetics, University of Lausanne, Lausanne Switzerland.
Guy BoivinResearch center in Infectious Diseases, CHU of Quebec and Laval University, Quebec city, Canada.
Pierre-Yves BochudInfectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-2208-4757
University of Lausanne · CHUniversité Laval · CAFribourg Development Agency · CHSIB Swiss Institute of Bioinformatics · CHLaboratoire National de Santé · LUUniversity of Leicester · GB

Funding

CIHR 148361
6 · The paper itself

Abstract

We report here two cases of Herpes simplex virus encephalitis (HSE) in adult patients with very rare, previously uncharacterized, non synonymous heterozygous G634R and R203W substitution in mannan-binding lectin serine protease 2 (MASP2), a gene encoding a key protease of the lectin pathway of the complement system. None of the 2 patients had variants in genes involved in the TLR3-interferon signaling pathway. Both MASP2 variants induced functional defects in vitro, including a reduced (R203W) or abolished (G634R) protein secretion, a lost capability to cleave MASP-2 precursor into its active form (G634R) and an in vivo reduced antiviral activity (G634R). In a murine model of HSE, animals deficient in mannose binding lectins (MBL, the main pattern recognition molecule associated with MASP-2) had a decreased survival rate and an increased brain burden of HSV-1 compared to WT C57BL/6J mice. Altogether, these data suggest that MASP-2 deficiency can increase susceptibility to adult HSE.

Indexed as

AdultAnimalsEncephalitis, Herpes SimplexHumansImmunity, InnateLectinsMaleMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMice, Inbred C57BLMice, TransgenicLectinsMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMASP2 protein, humanMASP-2 protein, mouse

Identifiers

PMID31869396
PMCPMC6944389
OpenAlexW2995448165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.