Evidence map›Paper›PMID 31869353›Full record

ArticlePloS one2019

Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.

Lihua Qin, Kyung J Ahn, Lara Wine Lee, Charles de Charleroy, E Bryan Crenshaw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Lihua QinDivision of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Kyung J AhnDivision of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Lara Wine LeeDivision of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Charles de CharleroyDivision of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
E Bryan CrenshawDivision of Pediatric Otolaryngology, Mammalian Neurogenetics Group, Center for Childhood Communication, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0002-0185-9066
Children's Hospital of Philadelphia · US

Funding

Genetic Analysis of Mammalian CNS DevelopmentR01NS039159 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CRENSHAW, E BRYAN · 2001 to 2004
$1.3M
NINDS NIH HHS R01 NS039159
6 · The paper itself

Abstract

Bone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate from the rhombic lip, near the roof plate, BMP signaling may regulate the development of these nuclei. To test this hypothesis genetically, we have examined the development of the hindbrain in BMP type I receptor knockout mice. Our results demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei, which give rise to cerebellar mossy fibers, but is not required for the development of the inferior olivary nucleus, which gives rise to cerebellar climbing fibers.

Indexed as

Signal TransductionAnimalsBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsGene Expression Regulation, DevelopmentalGene Knockout TechniquesMiceMice, KnockoutNerve FibersNeurogenesisRhombencephalonBmpr1a protein, mouseBmpr1b protein, mouseBone Morphogenetic Protein Receptors, Type IBone Morphogenetic Proteins

Identifiers

PMID31869353
PMCPMC6927620
OpenAlexW2994908931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.