Evidence map›Paper›PMID 31869199›Full record

ArticleACS chemical biology2020

Site-Specific Siderocalin Binding to Ferric and Ferric-Free Enterobactin As Revealed by Mass Spectrometry.

Chunyang Guo, Lindsey K Steinberg, Ming Cheng, Jong Hee Song, Jeffrey P Henderson, Michael L Gross

Open access · bronzeAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of lipocalin-2 in amyotrophic lateral sclerosis.Frontiers in aging neuroscience · 2025
    Review
  4. MSe Collision Energy Optimization for the Analysis of Membrane Proteins Using HDX-cIMS.Journal of the American Society for Mass Spectrometry · 2024
    Article
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  8. UropathogenicbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
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  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chunyang GuoDepartment of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
Lindsey K SteinbergDivision of Infectious Diseases, Department of Medicine, the Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Ming ChengDepartment of Chemistry, Washington University, St. Louis, Missouri 63130, United States.ORCID 0000-0002-1581-6382
Jong Hee SongDepartment of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
Jeffrey P HendersonDivision of Infectious Diseases, Department of Medicine, the Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-1755-3202
Michael L GrossDepartment of Chemistry, Washington University, St. Louis, Missouri 63130, United States.ORCID 0000-0003-1159-4636
Washington University in St. Louis · US

Funding

TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Metabolomic Signatures of Urologic Chronic Pelvic Pain SyndromeR01DK125860 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2021 to 2025
$2.8M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
EXPRESSION AND IRON-INDEPENDENT FUNCTIONS OF SIDEROPHORES IN URINARY TRACT INFECTR01DK099534 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2014 to 2018
$1.8M
Metabolomic Mechanisms of Nutritional Immunity in the Urinary TractR01DK111930 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2018 to 2021
$1.4M
A MASS SPECTROMETER FOR PROTEIN FOOTPRINTINGS10OD016298 · OD · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2014 to 2014
$450k
NIDDK NIH HHS R01 DK099534NIDDK NIH HHS R01 DK111930NIDDK NIH HHS R01 DK125860NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766NIH HHS S10 OD016298
6 · The paper itself

Abstract

Both host and pathogen competitively manipulate coordination environments during bacterial infections. Human cells release the innate immune protein siderocalin (Scn, also known as lipocalin-2/Lcn2, neutrophil gelatinase-associated lipocalin/NGAL) that can inhibit bacterial growth by sequestering iron in a ferric complex with enterobactin (Ent), the ubiquitous

Indexed as

Amino AcidsBinding SitesCarrier ProteinsCoordination ComplexesDeuteriumEnterobactinEscherichia coliFerric CompoundsHumansIsotope LabelingLigandsLipocalin-2Mass SpectrometryPeptidesProtein ConformationSiderophoresAmino AcidsCarrier ProteinsCoordination ComplexesDeuteriumEnterobactinFerric CompoundsferrienterochelinLCN2 protein, humanLigandsLipocalin-2PeptidesSiderophores

Identifiers

PMID31869199
PMCPMC7236765
OpenAlexW2997385412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.