Evidence map›Paper›PMID 31868913›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2020

Estimated Burden of Community-Onset Respiratory Syncytial Virus-Associated Hospitalizations Among Children Aged <2 Years in the United States, 2014-15.

Carmen S Arriola, Lindsay Kim, Gayle Langley, Evan J Anderson, Kyle Openo, Andrew M Martin, Ruth Lynfield, Erica Bye, Kathy Como-Sabetti, Arthur Reingold and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Carmen S ArriolaInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lindsay KimDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Gayle LangleyDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Evan J AndersonDepartments of Medicine and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Kyle OpenoGeorgia Emerging Infections Program, Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
Andrew M MartinGeorgia Emerging Infections Program, Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
Ruth LynfieldMinnesota Department of Health, St. Paul, Minnesota, USA.
Erica ByeMinnesota Department of Health, St. Paul, Minnesota, USA.
Kathy Como-SabettiMinnesota Department of Health, St. Paul, Minnesota, USA.
Arthur ReingoldCalifornia Emerging Infections Program, Oakland, California, USA.
Shua ChaiCalifornia Emerging Infections Program, Oakland, California, USA.
Pam DailyCalifornia Emerging Infections Program, Oakland, California, USA.
Ann ThomasOregon Public Health Division, Portland, Oregon.
Courtney CrawfordOregon Public Health Division, Portland, Oregon.
C ReedInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
S GargInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sandra S ChavesInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a major cause of hospitalizations in young children. We estimated the burden of community-onset RSV-associated hospitalizations among US children aged <2 years by extrapolating rates of RSV-confirmed hospitalizations in 4 surveillance states and using probabilistic multipliers to adjust for ascertainment biases.

methodsFrom October 2014 through April 2015, clinician-ordered RSV tests identified laboratory-confirmed RSV hospitalizations among children aged <2 years at 4 influenza hospitalization surveillance network sites. Surveillance populations were used to estimate age-specific rates of RSV-associated hospitalization, after adjusting for detection probabilities. We extrapolated these rates using US census data.

resultsWe identified 1554 RSV-associated hospitalizations in children aged <2 years. Of these, 27% were admitted to an intensive care unit, 6% needed mechanical ventilation, and 5 died. Most cases (1047/1554; 67%) had no underlying condition. Adjusted age-specific RSV hospitalization rates per 100 000 population were 1970 (95% confidence interval [CI],1787 to 2177), 897 (95% CI, 761 to 1073), 531 (95% CI, 459 to 624), and 358 (95% CI, 317 to 405) for ages 0-2, 3-5, 6-11, and 12-23 months, respectively. Extrapolating to the US population, an estimated 49 509-59 867 community-onset RSV-associated hospitalizations among children aged <2 years occurred during the 2014-2015 season.

conclusionsOur findings highlight the importance of RSV as a cause of hospitalization, especially among children aged <2 months. Our approach to estimating RSV-related hospitalizations could be used to provide a US baseline for assessing the impact of future interventions.

Indexed as

Age FactorsCommunity-Acquired InfectionsFemaleHospitalizationHumansInfantInfant, NewbornInfluenza, HumanIntensive Care UnitsMalePopulation SurveillanceRespiration, ArtificialRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRisk FactorsUnited Stateschildrendisease burdenRSV

Identifiers

PMID31868913
PMCPMC7107566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.