Evidence map›Paper›PMID 31868749›Full record

ArticleJournal of synchrotron radiation2020

Methods for dynamic synchrotron X-ray respiratory imaging in live animals.

Kaye Susannah Morgan, David Parsons, Patricia Cmielewski, Alexandra McCarron, Regine Gradl, Nigel Farrow, Karen Siu, Akihisa Takeuchi, Yoshio Suzuki, Kentaro Uesugi and 10 more

Abstract read
In one paragraph

Article in Journal of synchrotron radiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  6. Phase-contrast virtual chest radiography.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kaye Susannah MorganSchool of Physics and Astronomy, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
David ParsonsRobinson Research Institute, University of Adelaide, SA 5006, Australia.
Patricia CmielewskiRobinson Research Institute, University of Adelaide, SA 5006, Australia.ORCID 0000-0002-2236-9410
Alexandra McCarronRobinson Research Institute, University of Adelaide, SA 5006, Australia.
Regine GradlInstitute for Advanced Study, Technische Universität München, Garching Germany.
Nigel FarrowRobinson Research Institute, University of Adelaide, SA 5006, Australia.
Karen SiuSchool of Physics and Astronomy, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
Akihisa TakeuchiSPring-8, Japan Synchrotron Radiation Institute, Kouto, Hyogo, Japan.
Yoshio SuzukiSPring-8, Japan Synchrotron Radiation Institute, Kouto, Hyogo, Japan.
Kentaro UesugiSPring-8, Japan Synchrotron Radiation Institute, Kouto, Hyogo, Japan.ORCID 0000-0003-2579-513X
Masayuki UesugiSPring-8, Japan Synchrotron Radiation Institute, Kouto, Hyogo, Japan.
Naoto YagiSPring-8, Japan Synchrotron Radiation Institute, Kouto, Hyogo, Japan.ORCID 0000-0003-1792-2733
Chris HallImaging and Medical Beamline, The Australian Synchrotron - ANSTO, 800 Blackburn Road, Clayton, VIC 3168, Australia.ORCID 0000-0001-8691-7677
Mitzi KleinImaging and Medical Beamline, The Australian Synchrotron - ANSTO, 800 Blackburn Road, Clayton, VIC 3168, Australia.
Anton MaksimenkoImaging and Medical Beamline, The Australian Synchrotron - ANSTO, 800 Blackburn Road, Clayton, VIC 3168, Australia.
Andrew StevensonImaging and Medical Beamline, The Australian Synchrotron - ANSTO, 800 Blackburn Road, Clayton, VIC 3168, Australia.ORCID 0000-0002-0691-6883
Daniel HausermannImaging and Medical Beamline, The Australian Synchrotron - ANSTO, 800 Blackburn Road, Clayton, VIC 3168, Australia.
Martin DierolfChair of Biomedical Physics and Munich School of BioEngineering, Technische Universität München, 85748 Garching, Germany.ORCID 0000-0001-5150-2949
Franz PfeifferInstitute for Advanced Study, Technische Universität München, Garching Germany.
Martin DonnelleyRobinson Research Institute, University of Adelaide, SA 5006, Australia.

Funding

National Health and Medical Research Council (Australia) GNT1079712
6 · The paper itself

Abstract

Small-animal physiology studies are typically complicated, but the level of complexity is greatly increased when performing live-animal X-ray imaging studies at synchrotron and compact light sources. This group has extensive experience in these types of studies at the SPring-8 and Australian synchrotrons, as well as the Munich Compact Light Source. These experimental settings produce unique challenges. Experiments are always performed in an isolated radiation enclosure not specifically designed for live-animal imaging. This requires equipment adapted to physiological monitoring and test-substance delivery, as well as shuttering to reduce the radiation dose. Experiment designs must also take into account the fixed location, size and orientation of the X-ray beam. This article describes the techniques developed to overcome the challenges involved in respiratory X-ray imaging of live animals at synchrotrons, now enabling increasingly sophisticated imaging protocols.

Indexed as

Respiratory MechanicsSynchrotronsAerosolsAnesthesia, GeneralAnimalsAutopsyBody SizeBody TemperatureHumidifiersMicePentobarbitalRadiation DosageRadiographyRatsRespiration, ArtificialRespiratory SystemAerosolsPentobarbitalairwaysbiomedical imaginginverse Compton sourcelungsmousephase contrastphase-contrast imagingrattrachea

Identifiers

PMID31868749
PMCPMC6927518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.