ArticleJournal of Parkinson's disease2020
The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.
Article in Journal of Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Association of Rare Variants in ARSA with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Pooled it
- Prevalence of freezing of gait in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2021Pooled it
- Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.Annals of neurology · 2021Pooled it
- Weighing Open Science Against Research Participation Burden in Informed Consent: A Randomized Pilot Study.Journal of empirical research on human research ethics : JERHRE · 2025Trial
- Rare-Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Open neuroinformatics infrastructure ecosystem for federated multisite studies.bioRxiv : the preprint server for biology · 2026Article
- ThemedRxiv : the preprint server for health sciences · 2026Article
- Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Lack of association between G6PD variants and Parkinson disease.HGG advances · 2026Article
- MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.NPJ Parkinson's disease · 2025Article
- Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.NPJ Parkinson's disease · 2025Article
- Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Translational Informatics Driven Drug Repositioning for Neurodegenerative Disease.Current neuropharmacology · 2025Review
- Oculomotor indicators of cognitive performance are modulated by neurodegeneration.Frontiers in neurology · 2025Article
- Are rare heterozygous SYNJ1 variants associated with Parkinson's disease?NPJ Parkinson's disease · 2024Article
- Parkinson's disease CA2-CA3 hippocampal atrophy is accompanied by increased cholinergic innervation in patients with normal cognition but not in patients with mild cognitive impairment.Brain imaging and behavior · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
- Are rare heterozygousmedRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
29 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundGenetic, biologic and clinical data suggest that Parkinson's disease (PD) is an umbrella for multiple disorders with clinical and pathological overlap, yet with different underlying mechanisms. To better understand these and to move towards neuroprotective treatment, we have established the Quebec Parkinson Network (QPN), an open-access patient registry, and data and bio-samples repository.
objectiveTo present the QPN and to perform preliminary analysis of the QPN data.
methodsA total of 1,070 consecutively recruited PD patients were included in the analysis. Demographic and clinical data were analyzed, including comparisons between males and females, PD patients with and without RBD, and stratified analyses comparing early and late-onset PD and different age groups.
resultsQPN patients exhibit a male:female ratio of 1.8:1, an average age-at-onset of 58.6 years, an age-at-diagnosis of 60.4 years, and average disease duration of 8.9 years. REM-sleep behavior disorder (RBD) was more common among men, and RBD was associated with other motor and non-motor symptoms including dyskinesia, fluctuations, postural hypotension and hallucinations. Older patients had significantly higher rates of constipation and cognitive impairment, and longer disease duration was associated with higher rates of dyskinesia, fluctuations, freezing of gait, falls, hallucinations and cognitive impairment. Since QPN's creation, over 60 studies and 30 publications have included patients and data from the QPN.
conclusionsThe QPN cohort displays typical PD demographics and clinical features. These data are open-access upon application (http://rpq-qpn.ca/en/), and will soon include genetic, imaging and bio-samples. We encourage clinicians and researchers to perform studies using these resources.
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