ReviewThe British journal of radiology2020
Neutron dose and its measurement in proton therapy-current State of Knowledge.
Review in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Risk of secondary malignant neoplasms in children following proton therapy vs. photon therapy for primary CNS tumors: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Article
- Individualized Dose-volume Reconstruction Workflow for the Normal Tissues of Pediatric Patients Treated with Passive Scattering Proton Therapy.Radiation research · 2026Article
- Fluorescent nuclear track detectors for out-of-field neutron dosimetry in proton therapy.Medical physics · 2026Article
- Monte Carlo simulation and unfolding of an extended Bonner sphere system for secondary neutron spectrometry in proton therapy facilities using conventional BSS experimental data.Frontiers in oncology · 2026Article
- Safety of Contemporary Radiation Therapy in Patients With Cardiac Implantable Electronic Devices: Implications for Clinical Practice.Journal of the American Heart Association · 2025Article
- MONTE CARLO STUDY OF NEUTRON SPECTRA UNFOLDING FOR A PROTON BEAM USING MLEM.Radiation physics and chemistry (Oxford, England : 1993) · 2025Article
- Out-of-field neutron radiation from clinical proton, helium, carbon, and oxygen ion beams.Medical physics · 2025Article
- Review
- Navigating Complexities: Leadless Pacemaker Management in Proton Therapy for a Pacemaker-Dependent Bilateral Breast Cancer Patient.International journal of particle therapy · 2024Article
- First independent validation of the proton-boron capture therapy concept.Scientific reports · 2024Article
- A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system.Physics in medicine and biology · 2024Article
- Fetal dose assessment in a pregnant patient with brain tumor: A comparative study of proton PBS and 3DCRT/VMAT radiation therapy techniques.Journal of applied clinical medical physics · 2024Article
- Secondary neutron dosimetry for conformal FLASH proton therapy.Medical physics · 2024Article
- Development of a digital star-shot analysis system for comparing radiation and imaging isocenters of proton treatment machine.Journal of applied clinical medical physics · 2024Article
- Challenges and opportunities for proton therapy during pregnancy.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Risk of second primary cancer from proton arc therapy of pediatric brain tumors.Physics and imaging in radiation oncology · 2023Article
- Measurements of fetal dose with Mevion S250i proton therapy system with HYPERSCAN.Journal of applied clinical medical physics · 2023Article
- Comparison of out-of-field normal tissue dose estimates for pencil beam scanning proton therapy: MCNP6, PHITS, and TOPAS.Biomedical physics & engineering express · 2022Article
- Spot-scanning proton therapy for targets with adjacent cardiac implantable electronic devices - Strategies for breast and head & neck cancer.Physics and imaging in radiation oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton therapy has shown dosimetric advantages over conventional radiation therapy using photons. Although the integral dose for patients treated with proton therapy is low, concerns were raised about late effects like secondary cancer caused by dose depositions far away from the treated area. This is especially true for neutrons and therefore the stray dose contribution from neutrons in proton therapy is still being investigated. The higher biological effectiveness of neutrons compared to photons is the main cause of these concerns. The gold-standard in neutron dosimetry is measurements, but performing neutron measurements is challenging. Different approaches have been taken to overcome these difficulties, for instance with newly developed neutron detectors. Monte Carlo simulations is another common technique to assess the dose from secondary neutrons. Measurements and simulations are used to develop analytical models for fast neutron dose estimations. This article tries to summarize the developments in the different aspects of neutron dose in proton therapy since 2017. In general, low neutron doses have been reported, especially in active proton therapy. Although the published biological effectiveness of neutrons relative to photons regarding cancer induction is higher, it is unlikely that the neutron dose has a large impact on the second cancer risk of proton therapy patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.