ArticleCNS neuroscience & therapeutics2020
microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Unraveling Let-7f in oncology: a tumor suppressor with emerging clinical significance.Frontiers in cell and developmental biology · 2026Review
- The Mechanism of Action of Exosomes Derived from Glioblastoma Cells.Current medicinal chemistry · 2025Review
- Let-7a-3p overexpression increases chemosensitivity to carmustine and synergistically promotes autophagy and suppresses cell survival in U87MG glioblastoma cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Let-7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway.Journal of cellular and molecular medicine · 2023Article
- LIN28B and Let-7 in Diffuse Midline Glioma: A Review.Cancers · 2023Review
- Targeting purine metabolism in ovarian cancer.Journal of ovarian research · 2022Review
- Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.CNS neuroscience & therapeutics · 2022Article
- Exploring the role of non-coding RNAs in autophagy.Autophagy · 2022Review
- The Metabolism Reprogramming of microRNA Let-7-Mediated Glycolysis Contributes to Autophagy and Tumor Progression.International journal of molecular sciences · 2021Review
- Noncoding RNAs involved in the STAT3 pathway in glioma.Cancer cell international · 2021Review
- Review
- Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress.CNS neuroscience & therapeutics · 2021Article
- Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2020Review
- microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3.CNS neuroscience & therapeutics · 2020Article
- A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulating evidence has highlighted the correlation between microRNAs (miRNAs) and the progression of glioma. However, the role of miR cluster MC-let-7a-1 ~ let-7d in glioma remains elusive. Thus, the current study aimed to investigate the effect of miR cluster MC-let-7a-1 ~ let-7d on glioma progression. METHODS AND
resultsMicroarray data analysis provided data indicating the involvement of miR cluster MC-let-7a-1 ~ let-7d in glioma via STAT3. The expression of let-7a-1, let-7d, let-7f-1, and miR cluster MC-let-7a-1 ~ let-7d was diminished in the glioma tissues and the cell lines. Additionally, our results revealed that STAT3 was a target gene of let-7d, let-7a-1, and let-7f-1, which was further verified by the dual-luciferase reporter gene assay. Moreover, STAT3 expression was negatively mediated by let-7a-1, let-7d, and let-7f-1. Up-regulated miR cluster MC-let-7a-1 ~ let-7d or silenced STAT3 suppressed cell proliferation but accelerated cell apoptosis and autophagy. Moreover, restrained tumor growth was identified in the nude mice treated with miR cluster MC-let-7a-1 ~ let-7d mimics or STAT3 siRNA.
conclusionTaken together, the miR cluster MC-let-7a-1 ~ let-7d promotes glioma cell autophagy and apoptosis by repressing STAT3. The current study highlights the potential of the miR cluster MC-let-7a-1 ~ let-7d as biomarkers and promising treatment strategies for glioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.