Evidence map›Paper›PMID 31868112›Full record

ArticleNanomedicine (London, England)2020

Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy.

Hongwei Chen, Xin Luan, Hayley J Paholak, Joseph P Burnett, Nicholas O Stevers, Kanokwan Sansanaphongpricha, Miao He, Alfred E Chang, Qiao Li, Duxin Sun

Abstract read
In one paragraph

Article in Nanomedicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  18. Immune modulations of the tumor microenvironment in response to phototherapy.Journal of innovative optical health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongwei ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Xin LuanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Hayley J PaholakDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Joseph P BurnettDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Nicholas O SteversDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Kanokwan SansanaphongprichaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Miao HeDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Alfred E ChangDepartment of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Qiao LiDepartment of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Duxin SunDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunotherapyAnimalsBreast NeoplasmsCD8-Positive T-LymphocytesCombined Modality TherapyCTLA-4 AntigenDisease Models, AnimalFemaleFerric CompoundsHumansHyperthermia, InducedImmune ToleranceMiceNanoparticlesPhototherapyT-Lymphocytes, RegulatoryCTLA-4 AntigenFerric Compoundsferric oxideanti-CTLA-4 immunotherapyimmunosuppressionphotothermal therapyTregstumor microenvironment

Identifiers

PMID31868112
PMCPMC7132783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.