Evidence map›Paper›PMID 31868000›Full record

ArticleDiabetes & vascular disease research

Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.

Kathrin Thiem, Geerte Hoeke, Enchen Zhou, Anneke Hijmans, Tom Houben, Margien G Boels, Isabel M Mol, Esther Lutgens, Ronit Shiri-Sverdlov, Johan Bussink and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. CARD9 Regulation and its Role in Cardiovascular Diseases.International journal of biological sciences · 2022
    Review
  5. CARD9 Signaling, Inflammation, and Diseases.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Kathrin ThiemDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-8144-1294
Geerte HoekeDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Enchen ZhouDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Anneke HijmansDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Tom HoubenDepartments of Molecular Genetics, Human Biology and Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Margien G BoelsDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Isabel M MolDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Esther LutgensDivision of Experimental Vascular Biology, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Ronit Shiri-SverdlovDepartments of Molecular Genetics, Human Biology and Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Johan BussinkDepartment of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Thirumala D KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mariëtte R BoonDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Rinke StienstraDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Cees J TackDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Patrick Cn RensenDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Jimmy Fp BerbéeDivision of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Janna A van DiepenDepartment of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Leiden University Medical Center · NLRadboud University Nijmegen · NLMaastricht University · NLAmsterdam UMC Location University of Amsterdam · NLSt. Jude Children's Research Hospital · USUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesized that under hyperglycaemic conditions, as is the case in diabetes mellitus, glycosylated protein (sugar-like) structures activate C-type lectin receptors, leading to immune cell activation and increased atherosclerosis development.

methodsLow-density lipoprotein receptor-deficient mice were lethally irradiated and transplanted with bone marrow from control wild-type, RESULTS AND

conclusionDeletion of haematopoietic Dectin-2 reduced the number of circulating Ly6C

Indexed as

Gene DeletionAnimalsAntigens, LyAortaAortic DiseasesAtherosclerosisBiomarkersBlood GlucoseBone Marrow TransplantationCARD Signaling Adaptor ProteinsCells, CulturedCollagenCytokinesDiabetes Mellitus, ExperimentalDiet, WesternGenetic Predisposition to DiseaseAntigens, LyBiomarkersBlood GlucoseCard9 protein, mouseCARD Signaling Adaptor ProteinsCollagenCytokinesdectin-2, mouseLectins, C-TypeLy-6C antigen, mouseReceptors, LDLAtherosclerosisCARD9C-type lectin receptorsDectin-2hyperglycaemiainflammationmonocytes/macrophages

Identifiers

PMID31868000
PMCPMC7510497
OpenAlexW2996564914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.