Evidence map›Paper›PMID 31867988›Full record

ArticleJournal of diabetes science and technology2021

Hypoglycemia and Glycemic Control in Older Adults With Type 1 Diabetes: Baseline Results From the WISDM Study.

Anders L Carlson, Lauren G Kanapka, Kellee M Miller, Andrew J Ahmann, Naomi S Chaytor, Steven Fox, Lisa Kiblinger, Davida Kruger, Carol J Levy, Anne L Peters and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
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  6. Clin-STAR Corner: Practice Changing Advances in Diabetes Care.Journal of the American Geriatrics Society · 2025
    Review
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  15. Training and Support for Hybrid Closed-Loop Therapy.Journal of diabetes science and technology · 2022
    Article
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  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 1 country.

Anders L CarlsonPark Nicollet International Diabetes Center, Minneapolis, MN, USA.
Lauren G KanapkaJaeb Center for Health Research, Tampa, FL, USA.
Kellee M MillerJaeb Center for Health Research, Tampa, FL, USA.ORCID 0000-0002-1267-4841
Andrew J AhmannHarold Schnitzer Diabetes Health Center at Oregon Health and Science University, Portland, OR, USA.
Naomi S ChaytorElson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Steven FoxKeck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Lisa KiblingerAtlanta Diabetes Associates, Atlanta, GA, USA.
Davida KrugerHenry Ford Medical Center, Detroit, MI, USA.
Carol J LevyIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Anne L PetersKeck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Michael R RickelsRodebaugh Diabetes Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Maamoun SalamWashington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9789-6389
Viral N ShahBarbara Davis Center for Diabetes, Aurora, CO, USA.
Laura A YoungUniversity of North Carolina, Chapel Hill, NC, USA.
Yogish C KudvaMayo Clinic, Rochester, MN, USA.
Richard PratleyAdvent Health, Orlando, FL, USA.
WISDM Study Group
Jaeb Center for Health Research · USUniversity of Southern California · USAdventHealth Orlando · USAtlanta Diabetes Associates · USHenry Ford Hospital · USIcahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · USOregon Health & Science University · USPark Nicollet Clinic · USSansum Diabetes Research Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USWashington State University Spokane · USWashington University in St. Louis · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI FLEISCHER, NORMAN S. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
NCATS NIH HHS UL1 TR001878NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541
6 · The paper itself

Abstract

backgroundKnowledge regarding the burden and predictors of hypoglycemia among older adults with type 1 diabetes (T1D) is limited.

methodsWe analyzed baseline data from the Wireless Innovations for Seniors with Diabetes Mellitus (WISDM) study, which enrolled participants at 22 sites in the United States. Eligibility included clinical diagnosis of T1D, age ≥60 years, no real-time continuous glucose monitoring (CGM) use in prior three months, and HbA1c <10.0%. Blinded CGM data from 203 participants with at least 240 hours were included in the analyses.

resultsMedian age of the cohort was 68 years (52% female, 93% non-Hispanic white, and 53% used insulin pumps). Mean HbA1c was 7.5%. Median time spent in the glucose range <70 mg/dL was 5.0% (72 min/day) and <54 mg/dL was 1.6% (24 min/day). Among all factors analyzed, only reduced hypoglycemia awareness was associated with greater time spent <54 mg/dL (median time of 2.7% vs 1.3% [39 vs 19 minutes per day] for reduced awareness vs aware/uncertain, respectively,

conclusionsOver half of older T1D participants spent at least an hour a day with glucose levels <70 mg/dL. Those with reduced hypoglycemia awareness spent over twice as much time than those without in a serious hypoglycemia range (glucose levels <54 mg/dL). Interventions to reduce exposure to clinically significant hypoglycemia and increase time in range are urgently needed in this age group.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAgedBlood GlucoseBlood Glucose Self-MonitoringFemaleGlycated HemoglobinGlycemic ControlHumansHypoglycemic AgentsMaleMiddle AgedBlood GlucoseGlycated HemoglobinHypoglycemic Agentscontinuous glucose monitoringhyperglycemiahypoglycemiatype 1 diabetes

Identifiers

PMID31867988
PMCPMC8120041
OpenAlexW2995224057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.