ArticleBrain and behavior2020
Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats.Hormones and behavior · 2024Article
- Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CBBrain sciences · 2024Article
- Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms.Cellular and molecular life sciences : CMLS · 2024Article
- Protective Effects ofFood science of animal resources · 2023Article
- Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement.Biomedicines · 2023Article
- The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort.European archives of psychiatry and clinical neuroscience · 2023Article
- Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis.Scientific reports · 2023Article
- Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.Nature communications · 2022Article
- Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression.The international journal of neuropsychopharmacology · 2022Article
- Effects of Meranzin Hydrate On the LncRNA-miRNA-mRNA Regulatory Network in the Hippocampus of a Rat Model of Depression.Journal of molecular neuroscience : MN · 2022Article
- Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression.International journal of molecular sciences · 2021Article
- Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression.Pharmaceuticals (Basel, Switzerland) · 2021Article
- The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats.Frontiers in psychiatry · 2021Article
- Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression.Brain and behavior · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe present study was designed to explore the long-term differences between three mouse models for depression.
methodIn the present study, the unpredictable chronic mild stress (UCMS) model, the glucocorticoid/corticosterone model, and the olfactory bulbectomy model were compared at two, three, and five weeks after model induction. Behavioral testing performed included forced-swimming, tail suspension, open-field and elevated plus-maze tests. In addition, 5-hydroxytryptamine (5-HT) and dopamine levels, and mRNA and protein expressions related to 5-HT synthesis, transport, and signaling were analyzed in the hippocampus of tested animals.
resultsOur results revealed that each model demonstrated a specific profile of markers, whereas the stability of them differed over testing time.
conclusionsEach model provided a unique set of advantages that can be considered depending on the context and aims of each study. Among the three models, the UCMS model was mostly stable and appeared to the best model for testing long-term depression-like state.
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