Evidence map›Paper›PMID 31867753›Full record

ArticleProteins2020

ProDCoNN: Protein design using a convolutional neural network.

Yuan Zhang, Yang Chen, Chenran Wang, Chun-Chao Lo, Xiuwen Liu, Wei Wu, Jinfeng Zhang

Abstract read
In one paragraph

Article in Proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. GeoEvoBuilder: A deep learning framework for efficient functional and thermostable protein design.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Toward the appropriate interpretation of Alphafold2.Frontiers in artificial intelligence · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuan ZhangDepartment of Statistic, Florida State University, Tallahassee, Florida.
Yang ChenDepartment of Statistic, Florida State University, Tallahassee, Florida.
Chenran WangDepartment of Statistic, Florida State University, Tallahassee, Florida.
Chun-Chao LoDepartment of Statistic, Florida State University, Tallahassee, Florida.
Xiuwen LiuDepartment of Computer Science, Florida State University, Tallahassee, Florida.
Wei WuDepartment of Statistic, Florida State University, Tallahassee, Florida.
Jinfeng ZhangDepartment of Statistic, Florida State University, Tallahassee, Florida.ORCID 0000-0002-7429-7615

Funding

Collaborative Research: Mathematical Framework for Biomolecules: From Protein to RNA to ChromosomesR01GM126558 · NIGMS · FLORIDA STATE UNIVERSITY · PI ZHANG, JINFENG · 2017 to 2021
$1.5M
NIGMS NIH HHS R01 GM126558NIH HHS R01GM126558
6 · The paper itself

Abstract

Designing protein sequences that fold to a given three-dimensional (3D) structure has long been a challenging problem in computational structural biology with significant theoretical and practical implications. In this study, we first formulated this problem as predicting the residue type given the 3D structural environment around the C

Indexed as

Neural Networks, ComputerSoftwareAmino Acid SequenceDatabases, ProteinDatasets as TopicProtein EngineeringProteinsProtein Structure, SecondarySequence AlignmentProteinsconvolutional neural networkinverse folding problemProDCoNNprotein designprotein engineering

Identifiers

PMID31867753
PMCPMC8204568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.