Evidence map›Paper›PMID 31867717›Full record

ArticleClinical and experimental immunology2020

PLCε1 suppresses tumor growth by regulating murine T cell mobilization.

M Strazza, K Adam, A V Smrcka, S Lerrer, A Mor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M StrazzaColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
K AdamColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
A V SmrckaDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
S LerrerColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
A MorColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-2854-2405
Columbia University Irving Medical Center · USUniversity of Michigan · US

Funding

Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Novel mechanisms regulating PD-1 signaling and functionR01AI125640 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Mor · 2016 to 2026
$4.3M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
(PQ8) Predictive biomarkers for the onset of immune-related adverse events associated with PD-1 blockadeR21CA231277 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOR, ADAM · 2019 to 2020
$361k
NCI NIH HHS R21 CA231277NCRR NIH HHS S10 RR027050NIAID NIH HHS R01 AI125640NIGMS NIH HHS R35 GM127303NIH HHS S10 OD020056
6 · The paper itself

Abstract

Phospholipase C epsilon 1 (PLCε1) is a unique member of the phospholipase family, in that it also functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rap1. It is this function as a Rap1 GEF that gives PLCε1 an essential role in chemokine-mediated T cell adhesion. We have utilized a syngeneic tumor model, MC38 cells in C57BL/6 mice, and observed that tumors grow larger and more quickly in the absence of PLCε1. Single-cell analysis revealed an increased CD4

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell Line, TumorCell MovementChemokine CXCL12MaleMice, Inbred C57BLMice, KnockoutNeoplasms, ExperimentalPhosphoinositide Phospholipase CReceptors, CCR4Receptors, CXCR4T-LymphocytesTumor BurdenCcr4 protein, mouseChemokine CXCL12CXCR4 protein, mousePhosphoinositide Phospholipase Cphospholipase C epsilonReceptors, CCR4Receptors, CXCR4chemokinesMC38murine cancer modelphospholipase C epsilon 1SDF-1αT cells

Identifiers

PMID31867717
PMCPMC7066383
OpenAlexW2998011657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.