Evidence map›Paper›PMID 31867638›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2019

Anticipated Effects of Nicotine Reduction on Youth Smoking Initiation and Maintenance.

Suzanne M Colby, Rachel N Cassidy, Rachel Denlinger-Apte, Tracy T Smith, Lauren R Pacek, F Joseph McClernon, Jennifer W Tidey

Abstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Regulatory Approaches and Implementation of Minimally Addictive Combusted Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Pooled it
  2. Trial
  3. The Impact of Reducing Nicotine Content on Adolescent Cigarette Smoking and Nicotine Exposure: Results From a Randomized Controlled Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Trial
  4. Effects of Very Low Nicotine Content Cigarettes and Nicotine Vaping Device Characteristics on Choices to Smoke, Vape, or Abstain in Early Young Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. The Public Health Gains Had Cigarette Companies Chosen to Sell Very Low Nicotine Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Article
  10. Nicotine Standards in the United States.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suzanne M ColbyCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI.
Rachel N CassidyCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI.
Rachel Denlinger-ApteCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI.
Tracy T SmithDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC.
Lauren R PacekDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.
F Joseph McClernonDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.
Jennifer W TideyCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI.

Funding

VERY LOW NICOTINE CIGARETTES IN SMOKERS WITH SCHIZOPHRENIAU54DA031659 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LE, CHAP T. · 2011 to 2022
$64.7M
University of Vermont Tobacco Center of Regulatory ScienceU54DA036114 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HIGGINS, STEPHEN T · 2018 to 2022
$19.4M
Substance Abuse Intervention/Outcome Research TrainingT32DA016184 · NIDA · BROWN UNIVERSITY · PI Damaris J. Rohsenow, JENNIFER W. TIDEY · 2003 to 2026
$6.1M
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers-SupplementR01DA042532 · NIDA · DUKE UNIVERSITY · PI MCCLERNON, FRANCIS JOSEPH · 2016 to 2018
$1.5M
Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokersK01DA047433 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SMITH, TRACY TAYLOR · 2019 to 2023
$988k
Evaluation of Very Low Nicotine Content Cigarettes in Adolescent SmokersK01CA189300 · NCI · BROWN UNIVERSITY · PI CASSIDY, RACHEL N · 2014 to 2018
$897k
Mobile health interventions for varenicline adherence among HIV-positive smokersK01DA043413 · NIDA · DUKE UNIVERSITY · PI PACEK, LAUREN RENEE · 2017 to 2021
$860k
Assessing Tobacco Product Choice When the Cost of Menthol Cigarettes IncreasesR36DA045183 · NIDA · BROWN UNIVERSITY · PI DENLINGER-APTE, RACHEL · 2018 to 2019
$107k
NCI NIH HHS K01 CA189300NIDA NIH HHS K01 DA043413NIDA NIH HHS K01 DA047433NIDA NIH HHS R01 DA042532NIDA NIH HHS R36 DA045183NIDA NIH HHS T32 DA016184NIDA NIH HHS U54 DA031659NIDA NIH HHS U54 DA036114
6 · The paper itself

Abstract

This commentary summarizes emerging findings on the potential impact of a nicotine reduction policy on youth and young adults. We conclude that: (1) adolescent smokers and nonsmokers alike are likely to be less sensitive to reinforcement from very low nicotine content (VLNC) cigarettes compared with adults; (2) reducing nicotine in cigarettes to 0.4 mg/g would reduce the abuse potential of cigarettes in adolescents and young adults; (3) findings to date do not support concerns that nicotine reduction leads to compensatory smoking in young smokers; and (4) if the scope of a reduced nicotine product standard were applied to all combusted tobacco products, that would likely maximize public health benefit of this policy.

Indexed as

NicotineSmoking CessationTobacco ProductsAdolescentAdultHumansModels, StatisticalSmokersYoung AdultNicotine

Identifiers

PMID31867638
PMCPMC6939777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.