Evidence map›Paper›PMID 31867565›Full record

ArticleNature metabolism2019

m

Dario F De Jesus, Zijie Zhang, Sevim Kahraman, Natalie K Brown, Mengjie Chen, Jiang Hu, Manoj K Gupta, Chuan He, Rohit N Kulkarni

Abstract readLetter
In one paragraph

Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 2 syntheses or guidelines pooled it, 240 citations in OpenAlex.

  1. RNA methylation in vascular disease: a systematic review.Journal of cardiothoracic surgery · 2022
    Pooled it
  2. Pooled it
  3. Optimized GLORI-Seq of Chromatin-Associated RNAs.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  4. Review
  5. Article
  6. mNature metabolism · 2026
    Article
  7. Review
  8. Article
  9. Mettl14-mediated mJournal of endocrinological investigation · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Insulin signaling pathway related mNutrition & metabolism · 2026
    Article
  15. METTL16-mBMC biology · 2026
    Article
  16. Article
  17. NBiomolecules · 2026
    Review
  18. Article
  19. Article
  20. Review

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dario F De JesusIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8826-9095
Zijie ZhangDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-4900-506X
Sevim KahramanIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2880-6589
Natalie K BrownIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Mengjie ChenSection of Genetic Medicine, Department of Medicine, Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
Jiang HuIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Manoj K GuptaIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID 0000-0003-4319-7424
Rohit N KulkarniIslet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA. Rohit.Kulkarni@joslin.harvard.edu.ORCID 0000-0001-5029-6119
Brigham and Women's Hospital · USHoward Hughes Medical Institute · USUniversity of Chicago · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Role of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0M
Interplay Between SERPINB1 and TLR2/TLR4 in Beta Cell RegenerationR01DK117639 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, KULKARNI, ROHIT N. · 2019 to 2023
$3.0M
Role of SerpinB1 in beta cell growthR01DK103215 · NIDDK · JOSLIN DIABETES CENTER · PI KULKARNI, ROHIT N. · 2014 to 2018
$2.6M
Interrogation of dynamic RNA modifications in beta cells in type 1 diabetesUC4DK116278 · NIDDK · JOSLIN DIABETES CENTER · PI HE, CHUAN, KULKARNI, ROHIT N. · 2017 to 2017
$1.9M
Howard Hughes Medical InstituteNHGRI NIH HHS RM1 HG008935NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK067536NIDDK NIH HHS R01 DK103215NIDDK NIH HHS R01 DK117639NIDDK NIH HHS UC4 DK116278
6 · The paper itself

Abstract

The regulation of islet cell biology is critical for glucose homeostasis

Indexed as

AnimalsDiabetes Mellitus, Type 2HumansInsulin-Secreting CellsInsulin SecretionMethylationRNA, MessengerRNA, Messenger

Identifiers

PMID31867565
PMCPMC6924515
OpenAlexW2964606140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.