ArticleProceedings of the National Academy of Sciences of the United States of America1988
Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 81 citations in OpenAlex.
- A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia.Blood advances · 2023Article
- Article
- Review
- Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3.The Biochemical journal · 2004Article
- Role of platelet glycoprotein polymorphisms in cardiovascular diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2004Review
- Glanzmann thrombasthenia. Cooperation between sequence variants in cis during splice site selection.The Journal of clinical investigation · 1996Article
- Homologous recombination among three intragene Alu sequences causes an inversion-deletion resulting in the hereditary bleeding disorder Glanzmann thrombasthenia.American journal of human genetics · 1993Article
- Microsatellite polymorphism in the human platelet glycoprotein IIIa gene (GP3A) on chromosome 17.Nucleic acids research · 1992Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits.Immunogenetics · 1992Article
- Assignment of three rat integrin genes to chromosome 19 (ITGB1), chromosome 3 (ITGA4), and chromosome 7 (ITGA5).Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia.The Journal of clinical investigation · 1991Article
- Vitronectin receptor: tissue specific expression or adaptation to culture?International journal of experimental pathology · 1990Review
- Characterization of unr; a gene closely linked to N-ras.Nucleic acids research · 1990Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The fibrinogen receptor on human platelets is a prototypic member of the integrin family and is composed of subunit glycoproteins IIb (gpIIb) and IIIa (gpIIIa) in a 1:1 stoichiometric ratio. We have isolated cDNA clones for gpIIb and gpIIIa and localized both genes to chromosome 17. In the current study, several approaches were used to localize and map the genes for gpIIb and gpIIIa. A preliminary evaluation of subchromosomal localization was performed by using a panel of mouse-human somatic cell hybrids that contain different amounts of the long arm of human chromosome 17. Southern hybridization to the DNA of these hybrids shows that both genes map near the thymidine kinase gene. In situ hybridization to intact human chromosomes localized both genes to the 17q21-22 region. To better define the physical distance between the two genes, we examined the genomic hybridization pattern of each cDNA probe to high molecular weight restriction fragments separated by pulsed-field gel electrophoresis. Serial hybridizations of the same filter have allowed construction of long-range Mlu I and Sfi I restriction maps spanning more than 500 kilobases. Finally, nonoverlapping portions of the cDNAs for both gpIIb and gpIIIa were used to probe Sfi I digests of genomic DNA separated by field-inversion gels. This confirmed that the genes are physically linked within the same 260-kilobase Sfi I fragment and suggests that the gene for gpIIb is located on the 3' side of the gene for gpIIIa. These results suggest that coordinate expression of gpIIb and gpIIIa may depend on physical proximity.
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