Transformer mineral oil ingestion induces systemic sub-acute toxicity in Wistar rats.

Grace N Otunga, Geoffrey K Maiyoh, Benson N Macharia, Vivian C Tuei

Open access · goldAbstract read

In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Pathological analysis of batch safety testing of veterinary vaccines using small laboratory animals.Journal of toxicologic pathology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Grace N OtungaDepartment of Chemistry and Biochemistry, School of Science, University of Eldoret, P.O Box 1125-30100, Eldoret, Kenya.

Geoffrey K MaiyohDepartment of Medical Biochemistry, School of Medicine, Moi University, P.O Box 4606-30100, Eldoret, Kenya.

Benson N MachariaDepartment of Human Pathology and Forensic Medicine, School of Medicine, Moi University, P.O Box 4606-30100, Eldoret, Kenya.

Vivian C TueiDepartment of Chemistry and Biochemistry, School of Science, University of Eldoret, P.O Box 1125-30100, Eldoret, Kenya.

Moi University · KEUniversity of Eldoret · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the potential toxicities associated with the sub-acute ingestion of transformer mineral oil (TMO) at a heated low dose (HLD-50 mg/kg), heated high dose (HHD-500 mg/kg) and unheated high dose (UHD-500 mg/kg) in Wistar rats. There were increases in red blood cells and haemoglobin levels in HHD females and UHD males respectively versus control. The serum total proteins, albumin, and creatinine of the HHD females showed a significant increase versus control. The HHD males and UHD groups showed significant increase in liver malondialdehyde versus control. The livers of HHD groups had bile duct proliferation while those of HLD females and UHD groups showed focal areas of periportal chronic inflammation. HHD groups had kidneys with mild chronic inflammation and the HHD and UHD groups showed small intestines with chronic inflammation. In conclusion, sub-acute oral administration of TMO induced various degrees of dermal, haematological, hepatic, renal and small-intestinal toxicities in rats.

Indexed as

BiochemistryHematological systemIngestionLaboratory medicinePathologyRatSub-acuteToxicityToxicologyTransformer mineral oil

Identifiers

PMID31867465

DOI10.1016/j.heliyon.2019.e02998

PMCPMC6906677

OpenAlexW2992596513

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.