ArticleFrontiers in bioengineering and biotechnology2019
Potential of Manuka Honey as a Natural Polyelectrolyte to Develop Biomimetic Nanostructured Meshes With Antimicrobial Properties.
Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Layer-by-layer assembly: advancing skin repair, one layer at a time.RSC advances · 2025Review
- Advancements in Antimicrobial Textiles: Fabrication, Mechanisms of Action, and Applications.ACS omega · 2025Review
- Synergistic nanocoating with layer-by-layer functionalized PCL membranes enhanced by manuka honey and essential oils for advanced wound healing.Scientific reports · 2024Article
- Applications of honeybee-derived products in bone tissue engineering.Bone reports · 2024Review
- Article
- Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications.Pharmaceutics · 2022Review
- Valuable effect of Manuka Honey in increasing the printability and chondrogenic potential of a naturally derived bioink.Materials today. Bio · 2022Article
- A Review on Curcumin-Loaded Electrospun Nanofibers and their Application in Modern Medicine.JOM (Warrendale, Pa. : 1989) · 2022Review
- Antibiotic resistant bacteria: A bibliometric review of literature.Frontiers in public health · 2022Review
- "Green" Biomaterials: The Promising Role of Honey.Journal of functional biomaterials · 2021Review
- Potential effects of Saudi Shaoka (Saudi journal of biological sciences · 2021Article
- The Potential of Honeybee Products for Biomaterial Applications.Biomimetics (Basel, Switzerland) · 2021Review
- Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey againstAntibiotics (Basel, Switzerland) · 2020Article
- Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature.Clinical, cosmetic and investigational dermatology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of antibiotics has been the cornerstone to prevent bacterial infections; however, the emergency of antibiotic-resistant bacteria is still an open challenge. This work aimed to develop a delivery system for treating soft tissue infections for: (1) reducing the released antimicrobial amount, preventing drug-related systemic side effects; (2) rediscovering the beneficial effects of naturally derived agents; and (3) preserving the substrate functional properties. For the first time, Manuka honey (MH) was proposed as polyelectrolyte within the layer-by-layer assembly. Biomimetic electrospun poly(ε-caprolactone) meshes were treated via layer-by-layer assembly to obtain a multilayered nanocoating, consisting of MH as polyanion and poly-(allylamine-hydrochloride) as polycation. Physicochemical characterization demonstrated the successful nanocoating formation. Different cell lines (human immortalized and primary skin fibroblasts, and primary endothelial cells) confirmed positively the membranes cytocompatibility, while bacterial tests using Gram-negative and Gram-positive bacteria demonstrated that the antimicrobial MH activity was dependent on the concentration used and strains tested.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.