ArticleToxicology reports2020
The impact of particulate matter (PM2.5) on skin barrier revealed by transcriptome analysis: Focusing on cholesterol metabolism.
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies.Particle and fibre toxicology · 2020Pooled it
- Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways.Redox report : communications in free radical research · 2026Review
- Review
- A semi-analytical approach for solving a fractional-order mathematical model of skin cell damage and repair driven by environmental pollutants.Scientific reports · 2026Article
- The construction of HMME-PDT efficacy prediction model for port-wine stain based on machine learning algorithms.Scientific reports · 2025Article
- Independent and Combined Effects of Particulate Matter and Sleep Deprivation on Human Skin Barrier.Annals of dermatology · 2025Article
- Detection of reproductive and hematobiochemical biomarkers to evaluate the impact of heavy metal exposure on brick kiln workers.Scientific reports · 2025Article
- Association between PM2.5 and skin redness features in Taiwan.PLOS global public health · 2025Article
- SCAP/SREBP2-Mediated Cholesterol Biosynthetic Pathway Suppresses Particulate Matter-Induced Macrophage Activation and Airway Inflammation.Journal of inflammation research · 2025Article
- Review
- Non-linear association between air pollutants and secondary sensitive skin in acne patients.Journal of cosmetic dermatology · 2024Article
- PMHeliyon · 2024Article
- A review of factors influencing sensitive skin: an emphasis on built environment characteristics.Frontiers in public health · 2023Review
- Transcriptome Analysis of Particulate Matter 2.5-Induced Abnormal Effects on Human Sebocytes.International journal of molecular sciences · 2022Article
- Effect of GNWs/NiO-WOSensors (Basel, Switzerland) · 2022Article
- Inhibitory effect of main phenolic acid components ofFrontiers in pharmacology · 2022Article
- Fine Particulate Matter-Induced Oxidative Stress Mediated by UVA-Visible Light Leads to Keratinocyte Damage.International journal of molecular sciences · 2021Article
- Fisetin Protects HaCaT Human Keratinocytes from Fine Particulate Matter (PMAntioxidants (Basel, Switzerland) · 2021Article
- The role of xenobiotics in triggering psoriasis.Archives of toxicology · 2020Review
- Effects of Particulate Matter in a Mouse Model of Oxazolone-Induced Atopic Dermatitis.Annals of dermatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests that particulate matter (PM2.5), as a major air pollutant, imposes a certain degree of destruction and toxicity to the skin. It particularly impairs the structure and function of the epidermis. To study the impact of PM2.5 on the skin, transcriptome analysis was performed on PM2.5-exposed human primary keratinocytes. Functional annotation analysis demonstrates that PM2.5 significantly up-regulates cholesterol-metabolism-related genes. Via lipid extraction from PM2.5 treated three-dimensional epidermis tissue model (3D-ETM) and subsequent characterization via mass spectrometry, it was confirmed that PM2.5 significantly increases epidermal cholesterol levels
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.