Evidence map›Paper›PMID 31867206›Full record

ArticleLeukemia research reports2020

Association of genes

Darlen Cardoso Carvalho, Alayde Vieira Wanderley, Fernando Augusto Rodrigues Mello Junior, André Mauricio Ribeiro Dos Santos, Luciana Pereira Colares Leitão, Tatiane Piedade de Souza, Amanda de Nazaré Cohen Lima de Castro, Leandro Lopes de Magalhães, Marianne Rodrigues Fernandes, João Augusto Nunes de Carvalho Junior and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Children (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Article
  5. Polymorphism in theAfrican health sciences · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Darlen Cardoso CarvalhoNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Alayde Vieira WanderleyNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Fernando Augusto Rodrigues Mello JuniorNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
André Mauricio Ribeiro Dos SantosLaboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, Brazil.
Luciana Pereira Colares LeitãoNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Tatiane Piedade de SouzaNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Amanda de Nazaré Cohen Lima de CastroNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Leandro Lopes de MagalhãesLaboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, Brazil.
Marianne Rodrigues FernandesNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
João Augusto Nunes de Carvalho JuniorNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
André Salim KhayatNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Sidney SantosNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Paulo Pimentel de AssumpçãoNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Ney Pereira Carneiro Dos SantosNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil.
Centro de Pesquisas Oncológicas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.

Indexed as

AdmixedALLPediatricsPolymorphismsSusceptibility

Identifiers

PMID31867206
PMCPMC6906641
OpenAlexW2989662097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.