ArticleProceedings of the National Academy of Sciences of the United States of America1988
Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.Antioxidants & redox signaling · 2017Review
- TGF-beta, neuronal stem cells and glioblastoma.Oncogene · 2005Review
- Article
- The stumbler mutation maps to proximal mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of beta-spectrin.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Localization of the twitcher (twi) mutation on mouse chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Urogenital syndrome (us): a developmental mutation on chromosome 2 of the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Inherited haemolytic anaemia created by insertional inactivation of the alpha-spectrin gene.Transgenic research · 1992Article
- Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mouse chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Mouse chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Meiotic mapping of murine chromosome 17: the string of loci around l(17)-2Pas.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- A linkage map of distal mouse chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Mouse chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Mouse chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three genetic loci in the mouse affect the synthesis and assembly of the erythrocyte membrane skeleton. The spherocytosis and jaundiced loci affect the membrane skeletal protein known as spectrin. The normoblastosis locus affects the spectrin binding protein called ankyrin. We have obtained genetic data that define the linkage relationships among three spectrin genes and the spherocytosis and jaundiced loci. The erythroid alpha-spectrin gene is tightly linked to the spherocytosis locus on chromosome 1 and the jaundiced locus is on chromosome 12, tightly linked to the erythroid beta-spectrin gene. The brain alpha-spectrin (alpha-fodrin) gene is located on the centromeric end of chromosome 2 and is not closely linked to any previously mapped erythroid or neurological mutation. These results are consistent with the hypothesis that defects in the alpha- and beta-spectrin genes cause the spherocytosis and jaundiced hemolytic anemias in mice. All five loci studied are located within chromosomal segments that are conserved between mouse and man. Analysis of the data from the chromosome 12 study defines a new order for the genes on that chromosome and delineates the largest mouse/human conserved chromosomal segment yet known.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.