ArticleMolecular autism2019
Deviation from normative brain development is associated with symptom severity in autism spectrum disorder.
Article in Molecular autism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Digital tools for direct assessment of autism risk during early childhood: A systematic review.Autism : the international journal of research and practice · 2024Pooled it
- Different functional alteration in attention-deficit/hyperactivity disorder across developmental age groups: A meta-analysis and an independent validation of resting-state functional connectivity studies.CNS neuroscience & therapeutics · 2023Pooled it
- Unraveling the Individualized Shared and Distinct Dynamic Functional Connectivity in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome.CNS neuroscience & therapeutics · 2026Article
- Synchrony between brain age and internalising and externalising symptoms across adolescence.medRxiv : the preprint server for health sciences · 2026Article
- Decoding brain age predictions from sleep electroencephalography across infancy to adolescence.Scientific reports · 2025Article
- Diffusion trajectory of atypical morphological development in autism spectrum disorder.Communications biology · 2025Article
- Current challenges and future directions for brain age prediction in children and adolescents.Nature communications · 2025Review
- Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration.Human brain mapping · 2025Article
- Metabioethics and ChatGPT-based posthumous memories at the service of palliative medicine.Einstein (Sao Paulo, Brazil) · 2025Article
- EEG-based brain age prediction in infants-toddlers: Implications for early detection of neurodevelopmental disorders.Developmental cognitive neuroscience · 2025Article
- Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing.Autism research : official journal of the International Society for Autism Research · 2024Article
- Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions.Human brain mapping · 2024Article
- Aerobic exercise improves cognitive flexibility and modulates regional volume changes in a rat model of autism.Behavioural brain research · 2024Article
- Prediction of chronological age from resting-state EEG power in the first three years of life.medRxiv : the preprint server for health sciences · 2024Article
- Central Executive and Default Mode Networks: An Appraisal of Executive Function and Social Skill Brain-Behavior Correlates in Youth with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- A growth chart of brain function from infancy to adolescence based on EEG.EBioMedicine · 2024Article
- Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.Frontiers in human neuroscience · 2024Article
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- Intrinsic Structural Connectivity of the Default Mode Network and Behavioral Correlates of Executive Function and Social Skills in Youth with Autism Spectrum Disorders.Journal of autism and developmental disorders · 2023Article
- Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth.Biological psychiatry global open science · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Background: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition. The degree to which the brain development in ASD deviates from typical brain development, and how this deviation relates to observed behavioral outcomes at the individual level are not well-studied. We hypothesize that the degree of deviation from typical brain development of an individual with ASD would relate to observed symptom severity. Methods: The developmental changes in anatomical (cortical thickness, surface area, and volume) and diffusion metrics (fractional anisotropy and apparent diffusion coefficient) were compared between a sample of ASD ( Results: Machine learning model trained on all five metrics accurately predicted age in the TDC ( Limitations: This work investigated only linear relationships between five specific brain metrics and only one measure of ASD symptom severity in a limited age range. Reported effect sizes are moderate. Further work is needed to investigate developmental differences in other age ranges, other aspects of behavior, other neurobiological measures, and in an independent sample before results can be clinically applicable. Conclusions: Findings demonstrate that the degree of deviation from typical brain development relates to ASD symptom severity, partially accounting for the observed heterogeneity in ASD. Our approach enables characterization of each individual with reference to normative brain development and identification of distinct developmental subtypes, facilitating a better understanding of developmental heterogeneity in ASD.
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