ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2019
Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Diurnal Variation of 8-hydroxy-2'-deoxyguanosine in Continuous Time Series of Two Breast Cancer Survivors.Journal of circadian rhythms · 2025Article
- Methodological confounds of measuring urinary oxidative stress in wild animals.Ecology and evolution · 2022Article
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Authors and funding
3 authors.
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Abstract
introductionOxidative stress is a risk factor for life-style related diseases, including cancer. We recently reported that the oxidative stress marker 8-hydroxyguanine (8-OHGua) can be measured in saliva non-invasively. Understanding the diurnal pattern of salivary 8-OHGua levels is crucial for evaluating the oxidative stress. In this study, we analyzed the diurnal variation of salivary 8-OHGua levels.
findingsThe salivary 8-OHGua levels were relatively stable in the daytime (10:00-22:00). The daytime 8-OHGua levels seemed to represent the individual oxidative stress status. The average amount and the variation of the salivary 8-OHGua levels immediately after awakening were higher than those of the daytime levels.
conclusionsThe 8-OHGua levels in saliva exhibited diurnal variation. The levels were higher at the time of awakening. At this point, the daytime levels of salivary 8-OHGua may be appropriate for evaluating the individual oxidative stress status. Further study is needed for understanding and utilizing the 8-OHGua levels at the time of awakening.
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