Evidence map›Paper›PMID 31867038›Full record

ArticleFrontiers in genetics2019

Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis.

Joanna Pyczek, Natalia Khizanishvili, Maria Kuzyakova, Sebastian Zabel, Julia Bauer, Frauke Nitzki, Steffen Emmert, Michael P Schön, Petra Boukamp, Hans-Ulrich Schildhaus and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Spreading of IsolatedInternational journal of molecular sciences · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Joanna PyczekInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Natalia KhizanishviliInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Maria KuzyakovaInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Sebastian ZabelInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Julia BauerInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Frauke NitzkiInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Steffen EmmertDepartment of Dermatology and Venerology, University Medical Center Rostock, Rostock, Germany.
Michael P SchönDepartment of Dermatology, Venerology and Allergology, University Medical Center Goettingen, Goettingen, Germany.
Petra BoukampDivision of Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ) Heidelberg, Germany.
Hans-Ulrich SchildhausInstitute for Pathology, University Medical Center Goettingen, Goettingen, Germany.
Anja UhmannInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
Heidi HahnInstitute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany.
University of Göttingen · DEHeidelberg University · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Although current therapies are sufficient to clear the tumor in many cases, the overall risk of cSCC metastasis is still 5%. Alternative treatment options could help to overcome this situation. Here we focused on the role of the Hedgehog (HH) signaling pathway and its interplay with epidermal growth factor receptor (EGFR) signaling in cSCC. The analyses revealed that, despite lack of Sonic HH (SHH) expression, a subset of human cSCC can express

Indexed as

cutaneous squamous cell carcinomaepidermal growth factor receptorERKGLI1Hedgehog signaling

Identifiers

PMID31867038
PMCPMC6904360
OpenAlexW2993235783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.