Evidence map›Paper›PMID 31867011›Full record

ArticleFrontiers in immunology2019

Sequestration of Late Antigens Within Viral Factories Impairs MVA Vector-Induced Protective Memory CTL Responses.

Sha Tao, Ronny Tao, Dirk H Busch, Marek Widera, Heiner Schaal, Ingo Drexler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Surprisingly Effective Priming of CD8Journal of virology · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sha TaoInstitute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Ronny TaoInstitute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Dirk H BuschInstitute of Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany.
Marek WideraInstitute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Heiner SchaalInstitute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Ingo DrexlerInstitute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic CD8+ T cell (CTL) responses play an essential role in antiviral immunity. Here, we focused on the activation of CTL which recognize epitopes derived from viral or recombinant antigens with either early or late expression kinetics after infection with Modified Vaccinia Virus Ankara (MVA). Late antigens but not early antigens failed to efficiently stimulate murine CTL lines

Indexed as

Immunologic MemoryAnimalsAntigen PresentationAntigens, ViralGenetic VectorsHeLa CellsHistocompatibility Antigens Class IHumansLymphocyte ActivationMiceMice, Inbred C57BLProteasome Endopeptidase ComplexT-Lymphocytes, CytotoxicVaccinia virusAntigens, ViralHistocompatibility Antigens Class IProteasome Endopeptidase Complexantigen presentationCTLmemory T cell activationModified Vaccinia Virus Ankara (MVA)viral immunologyviral vector vaccine

Identifiers

PMID31867011
PMCPMC6904312
OpenAlexW2992080162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.