Evidence map›Paper›PMID 31866964›Full record

ArticleFrontiers in microbiology2019

Dendronized Silver Nanoparticles as Bacterial Membrane Permeabilizers and Their Interactions With

Karol Ciepluch, Kinga Skrzyniarz, Andrea Barrios-Gumiel, Sara Quintana, Javier Sánchez-Nieves, F Javier de la Mata, Barbara Maciejewska, Zuzanna Drulis-Kawa, Michał Arabski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Antimicrobial Effect of Silver Nanoparticles Capped withNanomaterials (Basel, Switzerland) · 2026
    Article
  2. AqueousNanomaterials (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Applications of silver nanoparticles synthesized fromBiotechnology notes (Amsterdam, Netherlands) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Antibacterial Effect of PEGylated Carbosilane Dendrimers onInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Review
  12. Review
  13. An Updated Review on Silver Nanoparticles in Biomedicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Karol CiepluchDepartment of Biochemistry and Genetics, Jan Kochanowski University, Kielce, Poland.
Kinga SkrzyniarzDepartment of Biochemistry and Genetics, Jan Kochanowski University, Kielce, Poland.
Andrea Barrios-GumielDepartment of Organic and Inorganic Chemistry, Chemistry Research Institute "Andrés M. del Río" (IQAR), University of Alcalá, Madrid, Spain.
Sara QuintanaDepartment of Organic and Inorganic Chemistry, Chemistry Research Institute "Andrés M. del Río" (IQAR), University of Alcalá, Madrid, Spain.
Javier Sánchez-NievesDepartment of Organic and Inorganic Chemistry, Chemistry Research Institute "Andrés M. del Río" (IQAR), University of Alcalá, Madrid, Spain.
F Javier de la MataDepartment of Organic and Inorganic Chemistry, Chemistry Research Institute "Andrés M. del Río" (IQAR), University of Alcalá, Madrid, Spain.
Barbara MaciejewskaDepartment of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wrocław, Wrocław, Poland.
Zuzanna Drulis-KawaDepartment of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wrocław, Wrocław, Poland.
Michał ArabskiDepartment of Biochemistry and Genetics, Jan Kochanowski University, Kielce, Poland.
Jan Kochanowski University · PLInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversity of Wrocław · PLBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial proteins, like lysozymes produced by animals or bacteriophage lysins, enable the degradation of bacterial peptidoglycan (PG) and, consequently, lead to bacterial cell lysis. However, the activity of those enzymes is not satisfactory against gram-negative bacteria because of the presence of an outer membrane (OM) barrier. Lytic enzymes can therefore be combined with membrane-disrupting agents, such as dendritic silver nanoparticles. Nevertheless, a lipopolysaccharide (LPS), especially the smooth type, could be the main hindrance for highly charged nanoparticles to get direct access to the bacterial OM and to help lytic enzymes to reach their target PG. Herein, we have investigated the interactions of PEGylated carbosilane dendritic nanoparticles with

Indexed as

endolysinlipopolysaccharidePEGylationpeptidoglycansilver nanoparticles

Identifiers

PMID31866964
PMCPMC6908850
OpenAlexW2992911892

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.