Evidence map›Paper›PMID 31866841›Full record

ArticleFrontiers in behavioral neuroscience2019

Lower Digit Ratio (2D:4D) Indicative of Excess Prenatal Androgen Is Associated With Increased Sociability and Greater Social Capital.

Verena N Buchholz, Christiane Mühle, Cohort Study on Substance Use Risk Factors, Johannes Kornhuber, Bernd Lenz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  3. The Molecular Basis of Love.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Verena N BuchholzAddiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland; Addiction Switzerland, Lausanne, Switzerland; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of the West of England, Frenchay Campus, Bristol, United Kingdom (Gerhard.Gmel@chuv.ch). La Source, School of Nursing Sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland (m.mohler-kuo@ecolelasource.ch). Institut für Epidemiologie, Biostatistik und Prävention, Hirschengraben, Zurich, Switzerland (simon.foster@kjpd.uzh.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (simon.marmet@chuv.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (Joseph.Studer@chuv.ch).
Christiane MühleAddiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland; Addiction Switzerland, Lausanne, Switzerland; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of the West of England, Frenchay Campus, Bristol, United Kingdom (Gerhard.Gmel@chuv.ch). La Source, School of Nursing Sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland (m.mohler-kuo@ecolelasource.ch). Institut für Epidemiologie, Biostatistik und Prävention, Hirschengraben, Zurich, Switzerland (simon.foster@kjpd.uzh.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (simon.marmet@chuv.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (Joseph.Studer@chuv.ch).
Cohort Study on Substance Use Risk Factors
Johannes KornhuberAddiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland; Addiction Switzerland, Lausanne, Switzerland; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of the West of England, Frenchay Campus, Bristol, United Kingdom (Gerhard.Gmel@chuv.ch). La Source, School of Nursing Sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland (m.mohler-kuo@ecolelasource.ch). Institut für Epidemiologie, Biostatistik und Prävention, Hirschengraben, Zurich, Switzerland (simon.foster@kjpd.uzh.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (simon.marmet@chuv.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (Joseph.Studer@chuv.ch).
Bernd LenzAddiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland; Addiction Switzerland, Lausanne, Switzerland; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of the West of England, Frenchay Campus, Bristol, United Kingdom (Gerhard.Gmel@chuv.ch). La Source, School of Nursing Sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne, Switzerland (m.mohler-kuo@ecolelasource.ch). Institut für Epidemiologie, Biostatistik und Prävention, Hirschengraben, Zurich, Switzerland (simon.foster@kjpd.uzh.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (simon.marmet@chuv.ch). Addiction Medicine, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland (Joseph.Studer@chuv.ch).
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positive social interactions are crucial for human well-being. Elevated prenatal exposure to testosterone as indicated by a low second-to-fourth finger length ratio (2D:4D) relates to more aggressive/hostile behavior in men of low 2D:4D, especially in challenging situations. How much people enjoy interacting with others is determined by the personality trait sociability. Given its role in approach and avoidance behavior, sociability might also be influenced by prenatal sex hormones, but studies are inconclusive so far. Here, we investigated the association between 2D:4D and the personality trait sociability complemented by personal social capital and personal social network size, in a population-based cohort of 4998 men. Lower 2D:4D correlated significantly with higher trait sociability, bigger personal social capital, and larger personal social network size. These effects were consistent across both hands separately and their mean value. Furthermore, both factors of sociability (1) liking party and company of friends and (2) isolation intolerance, correlated significantly with the prenatal testosterone marker. The exploratory analysis revealed no link between 2D:4D and responses to the personality trait aggression items or items of anti-social-personality disorder. Our data suggest that prenatal androgen exposure organizes the brain with lasting effects on social behavior.

Indexed as

2D:4Daggressiondigit ratioisolation intoleranceopioid receptorsociabilitysocial behavior

Identifiers

PMID31866841
PMCPMC6906175
OpenAlexW2981822591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.