ArticleFrontiers in neuroscience2019
Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Using ALE coordinate-based meta-analysis to observe resting-state brain abnormalities in subjective tinnitus.Brain imaging and behavior · 2024Pooled it
- Neuroplasticity and tinnitus: the role of Brain-Derived Neurotrophic Factor in pathogenesis and treatment.Frontiers in neuroscience · 2025Review
- Topological features of brain functional networks are reorganized during chronic tinnitus: A graph-theoretical study.The European journal of neuroscience · 2025Article
- [Progress in neural network mechanism of tinnitus using functional magnetic resonance imaging].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Disruptions of default mode network and precuneus connectivity associated with cognitive dysfunctions in tinnitus.Scientific reports · 2023Article
- Cognitive functioning and psychosomatic syndromes in a subjective tinnitus sample.Frontiers in psychology · 2023Article
- Resting-state Networks in Tinnitus : A Scoping Review.Clinical neuroradiology · 2022Article
- Recent-onset and persistent tinnitus: Uncovering the differences in brain activities using resting-state functional magnetic resonance imaging technologies.Frontiers in neuroscience · 2022Article
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
- Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- The Neural Mechanisms of Tinnitus: A Perspective From Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Review
- Stress and Tinnitus; Transcutaneous Auricular Vagal Nerve Stimulation Attenuates Tinnitus-Triggered Stress Reaction.Frontiers in psychology · 2020Article
- Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe phantom sound of tinnitus is considered to be associated with abnormal functional coupling between the nucleus accumbens (NAc) and the prefrontal cortex, which may form a frontostriatal top-down gating system to evaluate and modulate sensory signals. Resting-state functional magnetic resonance imaging (fMRI) was used to recognize the aberrant directional connectivity of the NAc in chronic tinnitus and to ascertain the relationship between this connectivity and tinnitus characteristics.
methodsParticipants included chronic tinnitus patients (
resultsCompared with healthy controls, tinnitus patients exhibited abnormal directional connectivity between the NAc and the prefrontal cortex, principally the middle frontal gyrus (MFG), orbitofrontal cortex (OFC), and inferior frontal gyrus (IFG). Additionally, positive correlations between tinnitus handicap questionnaire (THQ) scores and increased directional connectivity from the right NAc to the left MFG (
conclusionIn concurrence with expectations, tinnitus distress was correlated with enhanced directional connectivity between the NAc and the prefrontal cortex. The current study not only helps illuminate the neural basis of the frontostriatal gating control of tinnitus sensation but also contributes to deciphering the neuropathological features of tinnitus.
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